The article reviews the factors affecting therapeutic compliance from a patient's perspective. A qualitative literature review was conducted using the Medline database from 1970 to 2005, identifying 102 articles that met the inclusion criteria. The factors contributing to therapeutic non-compliance were categorized into patient-centered factors, therapy-related factors, social and economic factors, healthcare system factors, and disease factors. Patient-centered factors include demographic characteristics such as age, ethnicity, gender, education, and marital status, as well as psychological factors like beliefs, motivation, and negative attitudes towards therapy. Therapy-related factors involve the route of administration, treatment complexity, duration of treatment, medication side effects, and the degree of behavioral change required. Social and economic factors encompass time commitment, cost of therapy, income, and social support. Healthcare system factors include accessibility and satisfaction with healthcare facilities. Disease factors are related to the nature of the disease, such as the presence of symptoms and perceived health status. The review highlights the interaction between these factors and suggests that addressing therapy-related and healthcare system factors can positively impact compliance. However, psycho-social factors are classified as "soft" factors due to their complex and less quantifiable effects, emphasizing the need for further research to understand and address these factors effectively.The article reviews the factors affecting therapeutic compliance from a patient's perspective. A qualitative literature review was conducted using the Medline database from 1970 to 2005, identifying 102 articles that met the inclusion criteria. The factors contributing to therapeutic non-compliance were categorized into patient-centered factors, therapy-related factors, social and economic factors, healthcare system factors, and disease factors. Patient-centered factors include demographic characteristics such as age, ethnicity, gender, education, and marital status, as well as psychological factors like beliefs, motivation, and negative attitudes towards therapy. Therapy-related factors involve the route of administration, treatment complexity, duration of treatment, medication side effects, and the degree of behavioral change required. Social and economic factors encompass time commitment, cost of therapy, income, and social support. Healthcare system factors include accessibility and satisfaction with healthcare facilities. Disease factors are related to the nature of the disease, such as the presence of symptoms and perceived health status. The review highlights the interaction between these factors and suggests that addressing therapy-related and healthcare system factors can positively impact compliance. However, psycho-social factors are classified as "soft" factors due to their complex and less quantifiable effects, emphasizing the need for further research to understand and address these factors effectively.