This review explores the factors affecting therapeutic compliance from the patient's perspective. The study analyzed 102 articles published between 1970 and 2005 to identify common factors contributing to non-compliance. The factors were categorized into patient-centered, therapy-related, social and economic, healthcare system, and disease factors. While some factors had inconsistent effects on compliance, others were more clearly linked. The review highlights that compliance is often defined as adherence to healthcare providers' recommendations, and that terms like "adherence" and "concordance" are used interchangeably. The review found that compliance varies among different patient groups, with factors such as age, ethnicity, gender, education, and marital status influencing compliance. Older patients showed mixed results, with some studies indicating higher compliance and others suggesting lower compliance due to factors like cognitive impairment. Ethnicity was associated with compliance differences, possibly due to socio-economic status and language barriers. Gender had inconsistent effects, and educational level did not consistently predict compliance. Marital status had mixed results, with some studies showing that married patients were more compliant. Psychological factors, such as beliefs, motivation, and negative attitudes towards therapy, were also significant. Patients with positive beliefs about their treatment and motivation were more compliant. Negative attitudes, such as depression or fear of treatment, were linked to poor compliance. The patient-prescriber relationship was another key factor, with trust and communication playing a crucial role in compliance. Therapy-related factors, including the route of administration, treatment complexity, duration, side effects, and required behavioral changes, also influenced compliance. Patients with simpler regimens and fewer side effects were more likely to comply. Social and economic factors, such as cost, income, and access to healthcare, were significant, with financial strain and lack of access leading to non-compliance. Disease-related factors, such as fluctuating symptoms and perceived health status, also affected compliance. The review concludes that non-compliance remains a significant issue in healthcare, and that addressing these factors is crucial for improving outcomes. Factors like therapy-related issues, healthcare system accessibility, and disease characteristics are key areas for intervention. The review emphasizes the need for a systematic approach to understanding the interaction of these factors to improve compliance and healthcare outcomes.This review explores the factors affecting therapeutic compliance from the patient's perspective. The study analyzed 102 articles published between 1970 and 2005 to identify common factors contributing to non-compliance. The factors were categorized into patient-centered, therapy-related, social and economic, healthcare system, and disease factors. While some factors had inconsistent effects on compliance, others were more clearly linked. The review highlights that compliance is often defined as adherence to healthcare providers' recommendations, and that terms like "adherence" and "concordance" are used interchangeably. The review found that compliance varies among different patient groups, with factors such as age, ethnicity, gender, education, and marital status influencing compliance. Older patients showed mixed results, with some studies indicating higher compliance and others suggesting lower compliance due to factors like cognitive impairment. Ethnicity was associated with compliance differences, possibly due to socio-economic status and language barriers. Gender had inconsistent effects, and educational level did not consistently predict compliance. Marital status had mixed results, with some studies showing that married patients were more compliant. Psychological factors, such as beliefs, motivation, and negative attitudes towards therapy, were also significant. Patients with positive beliefs about their treatment and motivation were more compliant. Negative attitudes, such as depression or fear of treatment, were linked to poor compliance. The patient-prescriber relationship was another key factor, with trust and communication playing a crucial role in compliance. Therapy-related factors, including the route of administration, treatment complexity, duration, side effects, and required behavioral changes, also influenced compliance. Patients with simpler regimens and fewer side effects were more likely to comply. Social and economic factors, such as cost, income, and access to healthcare, were significant, with financial strain and lack of access leading to non-compliance. Disease-related factors, such as fluctuating symptoms and perceived health status, also affected compliance. The review concludes that non-compliance remains a significant issue in healthcare, and that addressing these factors is crucial for improving outcomes. Factors like therapy-related issues, healthcare system accessibility, and disease characteristics are key areas for intervention. The review emphasizes the need for a systematic approach to understanding the interaction of these factors to improve compliance and healthcare outcomes.