Factors associated with early-onset androgenetic alopecia: A scoping review

Factors associated with early-onset androgenetic alopecia: A scoping review

March 7, 2024 | Li-Ping Liu, Mary Adumo Wariboko, Xiao Hu, Zi-Han Wang, Qian Wu, Yu-Mei Li
This scoping review explores the risk factors, etiology, associated conditions, and adverse effects on well-being in early-onset androgenetic alopecia (AGA). The study included 65 eligible articles, with a majority being case-control studies (67.69%) and focusing on male patients (78.46%). Early-onset AGA was defined as cases developing before the age of 30 in 43.08% of the studies. The Hamilton–Norwood scale was the most frequently used method for evaluating severity in men (69.23%). Key risk factors included family history, cigarette smoking, unhealthy dietary habits, and high BMI. Early-onset AGA was also associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and susceptibility loci. Comorbidities included metabolic syndrome, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson’s disease. Men with early-onset AGA may have reduced treatment efficacy with certain medications, such as rosuvastatin, metformin, or lisinopril for dyslipidemia. The review highlights the multifactorial nature of early-onset AGA and emphasizes the importance of early detection, risk assessment, and comprehensive management to prevent long-term consequences.This scoping review explores the risk factors, etiology, associated conditions, and adverse effects on well-being in early-onset androgenetic alopecia (AGA). The study included 65 eligible articles, with a majority being case-control studies (67.69%) and focusing on male patients (78.46%). Early-onset AGA was defined as cases developing before the age of 30 in 43.08% of the studies. The Hamilton–Norwood scale was the most frequently used method for evaluating severity in men (69.23%). Key risk factors included family history, cigarette smoking, unhealthy dietary habits, and high BMI. Early-onset AGA was also associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and susceptibility loci. Comorbidities included metabolic syndrome, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson’s disease. Men with early-onset AGA may have reduced treatment efficacy with certain medications, such as rosuvastatin, metformin, or lisinopril for dyslipidemia. The review highlights the multifactorial nature of early-onset AGA and emphasizes the importance of early detection, risk assessment, and comprehensive management to prevent long-term consequences.
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Understanding Factors associated with early-onset androgenetic alopecia%3A A scoping review