The article "Fatigue and Cognitive Impairment in Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis" by Felicia Ceban et al. examines the prevalence and characteristics of fatigue and cognitive impairment in individuals 12 weeks or more after COVID-19 diagnosis. The study, conducted from database inception to June 8, 2021, included 81 studies, primarily from cohort designs, with a total sample size of 25,268 for fatigue and 13,232 for cognitive impairment. The meta-analysis found that 32% of individuals experienced fatigue, and 22% exhibited cognitive impairment. Subgroup analyses revealed higher rates of fatigue in females and adults compared to males and children, respectively. Objective assessments of fatigue were associated with higher proportions of affected individuals. Inflammatory markers were elevated in a subset of patients, and functional impairment was significant in many cases. The study also identified factors associated with an increased risk of PCS symptoms, including female sex, older age, pre-existing comorbidities, and greater severity of acute illness. The findings highlight the need for further research to understand the underlying mechanisms, develop diagnostic criteria, and establish treatments for fatigue and cognitive impairment in post-COVID-19 syndrome.The article "Fatigue and Cognitive Impairment in Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis" by Felicia Ceban et al. examines the prevalence and characteristics of fatigue and cognitive impairment in individuals 12 weeks or more after COVID-19 diagnosis. The study, conducted from database inception to June 8, 2021, included 81 studies, primarily from cohort designs, with a total sample size of 25,268 for fatigue and 13,232 for cognitive impairment. The meta-analysis found that 32% of individuals experienced fatigue, and 22% exhibited cognitive impairment. Subgroup analyses revealed higher rates of fatigue in females and adults compared to males and children, respectively. Objective assessments of fatigue were associated with higher proportions of affected individuals. Inflammatory markers were elevated in a subset of patients, and functional impairment was significant in many cases. The study also identified factors associated with an increased risk of PCS symptoms, including female sex, older age, pre-existing comorbidities, and greater severity of acute illness. The findings highlight the need for further research to understand the underlying mechanisms, develop diagnostic criteria, and establish treatments for fatigue and cognitive impairment in post-COVID-19 syndrome.