The article discusses the role of fatty acid-binding proteins (FABPs) in lipid-mediated biological processes and their significance in systemic metabolic homeostasis. FABPs are a group of intracellular proteins that bind hydrophobic ligands such as fatty acids, eicosanoids, and other lipids with high affinity. They play a crucial role in lipid trafficking, storage, and signaling, and are involved in the regulation of gene expression, growth, survival, and inflammatory responses. The article highlights the potential of FABPs as therapeutic targets for diseases such as obesity, diabetes, and atherosclerosis, particularly through the development of pharmacological agents that modify FABP function. The authors also review the structure and function of different FABP isoforms, including liver (L-FABP), intestinal (I-FABP), heart (H-FABP), adipocyte (A-FABP), epidermal (E-FABP), brain (B-FABP), and myelin (M-FABP) FABPs, and their roles in various physiological and pathological conditions. The article concludes by discussing the therapeutic potential of targeting FABPs, especially A-FABP, in treating metabolic diseases and other inflammatory conditions.The article discusses the role of fatty acid-binding proteins (FABPs) in lipid-mediated biological processes and their significance in systemic metabolic homeostasis. FABPs are a group of intracellular proteins that bind hydrophobic ligands such as fatty acids, eicosanoids, and other lipids with high affinity. They play a crucial role in lipid trafficking, storage, and signaling, and are involved in the regulation of gene expression, growth, survival, and inflammatory responses. The article highlights the potential of FABPs as therapeutic targets for diseases such as obesity, diabetes, and atherosclerosis, particularly through the development of pharmacological agents that modify FABP function. The authors also review the structure and function of different FABP isoforms, including liver (L-FABP), intestinal (I-FABP), heart (H-FABP), adipocyte (A-FABP), epidermal (E-FABP), brain (B-FABP), and myelin (M-FABP) FABPs, and their roles in various physiological and pathological conditions. The article concludes by discussing the therapeutic potential of targeting FABPs, especially A-FABP, in treating metabolic diseases and other inflammatory conditions.