Ferroptosis is a type of cell death characterized by iron overload, lipid peroxide accumulation, and reduced glutathione peroxidase 4 (GPX4) activity. It is involved in various diseases and is linked to metabolic syndrome (MetS) and its complications, such as obesity, type 2 diabetes mellitus (T2DM), and atherosclerosis. Recent studies have shown that ferroptosis-related molecules are associated with MetS and its consequences. This review discusses the mechanisms of ferroptosis, its regulatory factors, and its role in the pathogenesis of MetS. It also explores ferroptosis-targeted therapies and highlights key issues for future research. Ferroptosis is closely related to MetS, and targeting ferroptosis may offer new therapeutic strategies for MetS and its complications. The review also discusses the role of iron metabolism, lipid metabolism, and other pathways in ferroptosis. Ferroptosis inhibitors and inducers are classified, and their potential in treating MetS is discussed. The review concludes that ferroptosis is a promising therapeutic target for MetS and its complications.Ferroptosis is a type of cell death characterized by iron overload, lipid peroxide accumulation, and reduced glutathione peroxidase 4 (GPX4) activity. It is involved in various diseases and is linked to metabolic syndrome (MetS) and its complications, such as obesity, type 2 diabetes mellitus (T2DM), and atherosclerosis. Recent studies have shown that ferroptosis-related molecules are associated with MetS and its consequences. This review discusses the mechanisms of ferroptosis, its regulatory factors, and its role in the pathogenesis of MetS. It also explores ferroptosis-targeted therapies and highlights key issues for future research. Ferroptosis is closely related to MetS, and targeting ferroptosis may offer new therapeutic strategies for MetS and its complications. The review also discusses the role of iron metabolism, lipid metabolism, and other pathways in ferroptosis. Ferroptosis inhibitors and inducers are classified, and their potential in treating MetS is discussed. The review concludes that ferroptosis is a promising therapeutic target for MetS and its complications.