The article reviews the mechanisms and regulations of ferroptosis in cardiovascular diseases (CVDs), highlighting its role in various CVDs such as myocardial infarction, heart transplantation, atherosclerosis, and heart failure. Ferroptosis, a form of regulated cell death, involves iron regulation, metabolic mechanisms, and lipid peroxidation. The article discusses the subcellular organelles involved in ferroptosis, including the plasma membrane, endoplasmic reticulum (ER), mitochondria, peroxisomes, lysosomes, Golgi apparatus, lipid droplets, and the nucleus. It also explores the regulatory pathways of ferroptosis, such as iron metabolism, glutathione metabolism, and lipid metabolism. The article further examines the mechanisms of ferroptosis, including iron regulation, metabolic mechanisms, and lipid peroxidation, and highlights the role of specific proteins and pathways in inhibiting ferroptosis. Finally, it discusses the dual role of p53 in controlling ferroptosis and the involvement of the Hippo signaling pathway in regulating ferroptosis. The review aims to provide insights into the latest progress in understanding ferroptosis and its potential therapeutic targets for CVDs.The article reviews the mechanisms and regulations of ferroptosis in cardiovascular diseases (CVDs), highlighting its role in various CVDs such as myocardial infarction, heart transplantation, atherosclerosis, and heart failure. Ferroptosis, a form of regulated cell death, involves iron regulation, metabolic mechanisms, and lipid peroxidation. The article discusses the subcellular organelles involved in ferroptosis, including the plasma membrane, endoplasmic reticulum (ER), mitochondria, peroxisomes, lysosomes, Golgi apparatus, lipid droplets, and the nucleus. It also explores the regulatory pathways of ferroptosis, such as iron metabolism, glutathione metabolism, and lipid metabolism. The article further examines the mechanisms of ferroptosis, including iron regulation, metabolic mechanisms, and lipid peroxidation, and highlights the role of specific proteins and pathways in inhibiting ferroptosis. Finally, it discusses the dual role of p53 in controlling ferroptosis and the involvement of the Hippo signaling pathway in regulating ferroptosis. The review aims to provide insights into the latest progress in understanding ferroptosis and its potential therapeutic targets for CVDs.