The article discusses the rarity of retinoblastoma cases in Seascale, suggesting that the observed five cases are unusually high and not indicative of a general increase in incidence. It emphasizes that the extreme rarity of the disease makes it noteworthy. The authors argue that the data strongly suggest a link between socioeconomic status and residence in Seascale, but they caution against excluding radiation as a potential cause. They also highlight the importance of considering fertility and parenthood in patients with spinal cord injuries, noting recent improvements in these areas. Additionally, the article critiques a study by Kaplan and Salonen on the relationship between childhood socioeconomic conditions and adult ischemic heart disease, arguing that the methods used may not accurately capture the true association due to residual confounding. The authors suggest that a more sophisticated analysis is needed to isolate independent effects from intercorrelated risk factors.The article discusses the rarity of retinoblastoma cases in Seascale, suggesting that the observed five cases are unusually high and not indicative of a general increase in incidence. It emphasizes that the extreme rarity of the disease makes it noteworthy. The authors argue that the data strongly suggest a link between socioeconomic status and residence in Seascale, but they caution against excluding radiation as a potential cause. They also highlight the importance of considering fertility and parenthood in patients with spinal cord injuries, noting recent improvements in these areas. Additionally, the article critiques a study by Kaplan and Salonen on the relationship between childhood socioeconomic conditions and adult ischemic heart disease, arguing that the methods used may not accurately capture the true association due to residual confounding. The authors suggest that a more sophisticated analysis is needed to isolate independent effects from intercorrelated risk factors.