The first case of 2019-nCoV infection in the United States was reported on January 20, 2020, in Snohomish County, Washington. The patient, a 35-year-old man, presented with a 4-day history of cough and subjective fever after returning from Wuhan, China, on January 15. Despite initial mild symptoms, he developed pneumonia by day 9 of his illness. The case highlights the importance of close coordination between clinicians and public health authorities, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection. The patient was isolated and admitted to an airborne-isolation unit, where he received supportive care and treatment with remdesivir. By January 30, 2020, the patient's symptoms had resolved, except for a decreasing cough. The case underscores the importance of recognizing travel history and prompt isolation to prevent further transmission.The first case of 2019-nCoV infection in the United States was reported on January 20, 2020, in Snohomish County, Washington. The patient, a 35-year-old man, presented with a 4-day history of cough and subjective fever after returning from Wuhan, China, on January 15. Despite initial mild symptoms, he developed pneumonia by day 9 of his illness. The case highlights the importance of close coordination between clinicians and public health authorities, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection. The patient was isolated and admitted to an airborne-isolation unit, where he received supportive care and treatment with remdesivir. By January 30, 2020, the patient's symptoms had resolved, except for a decreasing cough. The case underscores the importance of recognizing travel history and prompt isolation to prevent further transmission.