The chapter discusses the analysis of single-channel records, focusing on two main objectives: qualitative observation and quantitative analysis. Qualitative analysis involves examining the results to identify features such as amplitude variations, burst patterns, and artifacts that may be misleading. Quantitative analysis aims to compare measured variables (e.g., channel-open durations) with theoretical distributions to infer biological mechanisms. The chapter emphasizes the importance of detailed analysis due to the random nature of the events recorded, such as channel open times, which often follow exponential distributions. To achieve accurate measurements, a large number of events ( typically 200 or more) are required, especially when the distribution is complex. The chapter also covers methods for acquiring data, including the use of transient recorders and computer systems. Transient recorders can be triggered by events and display the entire event on an oscilloscope, but they are too slow for large-scale analysis. Computer systems, either online or using magnetic tape, are more efficient for data acquisition and manipulation. Online systems allow for immediate data acquisition and real-time analysis, making them suitable for experiments where voltage pulses are applied to activate channels.The chapter discusses the analysis of single-channel records, focusing on two main objectives: qualitative observation and quantitative analysis. Qualitative analysis involves examining the results to identify features such as amplitude variations, burst patterns, and artifacts that may be misleading. Quantitative analysis aims to compare measured variables (e.g., channel-open durations) with theoretical distributions to infer biological mechanisms. The chapter emphasizes the importance of detailed analysis due to the random nature of the events recorded, such as channel open times, which often follow exponential distributions. To achieve accurate measurements, a large number of events ( typically 200 or more) are required, especially when the distribution is complex. The chapter also covers methods for acquiring data, including the use of transient recorders and computer systems. Transient recorders can be triggered by events and display the entire event on an oscilloscope, but they are too slow for large-scale analysis. Computer systems, either online or using magnetic tape, are more efficient for data acquisition and manipulation. Online systems allow for immediate data acquisition and real-time analysis, making them suitable for experiments where voltage pulses are applied to activate channels.