Flavonoids are a class of organic compounds characterized by phenolic structures, widely found in various natural sources such as fruits, vegetables, cereals, and beverages. This review focuses on the biological activities of seven common flavonoids: apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin. These flavonoids exhibit promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, as evidenced by in vitro, in vivo, and clinical studies. The review highlights recent trends, therapeutic interventions, and future aspects of flavonoids in treating diseases like diabetes, inflammation, bacterial and viral infections, cancers, and cardiovascular diseases. Despite encouraging findings, clinical research remains limited, hindering a comprehensive understanding of flavonoids' effects at different concentrations. Future studies should prioritize exploring bioavailability due to the potential for high inter-individual variation. This review aims to promote the identification and development of innovative therapeutic uses for flavonoids.Flavonoids are a class of organic compounds characterized by phenolic structures, widely found in various natural sources such as fruits, vegetables, cereals, and beverages. This review focuses on the biological activities of seven common flavonoids: apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin. These flavonoids exhibit promising anti-diabetic, anti-inflammatory, antibacterial, antioxidant, antiviral, cytotoxic, and lipid-lowering activities, as evidenced by in vitro, in vivo, and clinical studies. The review highlights recent trends, therapeutic interventions, and future aspects of flavonoids in treating diseases like diabetes, inflammation, bacterial and viral infections, cancers, and cardiovascular diseases. Despite encouraging findings, clinical research remains limited, hindering a comprehensive understanding of flavonoids' effects at different concentrations. Future studies should prioritize exploring bioavailability due to the potential for high inter-individual variation. This review aims to promote the identification and development of innovative therapeutic uses for flavonoids.