Flavonoids, a group of natural compounds with variable phenolic structures, are widely found in fruits, vegetables, grains, and beverages. They are known for their beneficial effects on health, including anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. These compounds are crucial in various nutraceutical, pharmaceutical, medicinal, and cosmetic applications. Research on flavonoids has been enhanced by their association with reduced cardiovascular mortality and prevention of coronary heart disease (CHD). Despite ongoing research, the exact mechanisms of flavonoids' actions are not fully understood. However, their biological activities have been recognized for centuries, and current trends in research focus on isolation, identification, characterization, and applications of flavonoids. Molecular docking and bioinformatics are also used to predict potential applications and manufacturing. This review discusses the current trends in flavonoid research, their mechanisms of action, functions, and applications, as well as their potential as drugs in preventing chronic diseases. Future research directions include further studies on bioavailability and dietary intake to enhance the health benefits of flavonoids.Flavonoids, a group of natural compounds with variable phenolic structures, are widely found in fruits, vegetables, grains, and beverages. They are known for their beneficial effects on health, including anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. These compounds are crucial in various nutraceutical, pharmaceutical, medicinal, and cosmetic applications. Research on flavonoids has been enhanced by their association with reduced cardiovascular mortality and prevention of coronary heart disease (CHD). Despite ongoing research, the exact mechanisms of flavonoids' actions are not fully understood. However, their biological activities have been recognized for centuries, and current trends in research focus on isolation, identification, characterization, and applications of flavonoids. Molecular docking and bioinformatics are also used to predict potential applications and manufacturing. This review discusses the current trends in flavonoid research, their mechanisms of action, functions, and applications, as well as their potential as drugs in preventing chronic diseases. Future research directions include further studies on bioavailability and dietary intake to enhance the health benefits of flavonoids.