The article reviews the potential of flavonoids as insecticides in crop protection, addressing their modes of action and mechanisms of bioactivity. Flavonoids, a class of polyphenols abundant in plants, have gained attention due to their biodegradability and low toxicity compared to traditional pesticides. The review discusses the structure-activity relationship of flavonoids and their impact on various insect pests, including caterpillars, flies, beetles, moths, and aphids. Flavonoids are found to disrupt feeding behavior, induce oxidative stress, affect detoxification enzymes, delay development, and disrupt the nervous system of insects. The review also addresses challenges associated with their application, such as toxicity to non-target organisms and biodegradability, and suggests encapsulation in biodegradable polymers to enhance efficiency and reduce environmental impact. Despite these challenges, flavonoids show promise as sustainable and safer alternatives to traditional pesticides.The article reviews the potential of flavonoids as insecticides in crop protection, addressing their modes of action and mechanisms of bioactivity. Flavonoids, a class of polyphenols abundant in plants, have gained attention due to their biodegradability and low toxicity compared to traditional pesticides. The review discusses the structure-activity relationship of flavonoids and their impact on various insect pests, including caterpillars, flies, beetles, moths, and aphids. Flavonoids are found to disrupt feeding behavior, induce oxidative stress, affect detoxification enzymes, delay development, and disrupt the nervous system of insects. The review also addresses challenges associated with their application, such as toxicity to non-target organisms and biodegradability, and suggests encapsulation in biodegradable polymers to enhance efficiency and reduce environmental impact. Despite these challenges, flavonoids show promise as sustainable and safer alternatives to traditional pesticides.