This review discusses the anti-inflammatory properties of flavonoids and their implications in cancer and cardiovascular disease. Chronic inflammation is increasingly linked to various pathological conditions, including arteriosclerosis, obesity, diabetes, neurodegenerative diseases, and cancer. The search for safe and effective anti-inflammatory treatments remains urgent. Flavonoids, a group of natural substances found in the diet, have shown promising anti-inflammatory effects. Their mechanisms of action include antioxidant activity, inhibition of eicosanoid-generating enzymes, and modulation of proinflammatory molecule production. Recent studies also indicate that some flavonoids can modulate proinflammatory gene expression, thereby reducing the inflammatory response. The review highlights the anti-inflammatory activities of specific flavonoids, such as quercetin, rutin, and genistein, and their potential in preventing and treating chronic diseases. The central role of inflammation in the development of cancer and cardiovascular disease is emphasized, along with the protective effects of flavonoids against these conditions.This review discusses the anti-inflammatory properties of flavonoids and their implications in cancer and cardiovascular disease. Chronic inflammation is increasingly linked to various pathological conditions, including arteriosclerosis, obesity, diabetes, neurodegenerative diseases, and cancer. The search for safe and effective anti-inflammatory treatments remains urgent. Flavonoids, a group of natural substances found in the diet, have shown promising anti-inflammatory effects. Their mechanisms of action include antioxidant activity, inhibition of eicosanoid-generating enzymes, and modulation of proinflammatory molecule production. Recent studies also indicate that some flavonoids can modulate proinflammatory gene expression, thereby reducing the inflammatory response. The review highlights the anti-inflammatory activities of specific flavonoids, such as quercetin, rutin, and genistein, and their potential in preventing and treating chronic diseases. The central role of inflammation in the development of cancer and cardiovascular disease is emphasized, along with the protective effects of flavonoids against these conditions.