This review discusses the development of electronic textiles (e-textiles) for personalized, intelligent healthcare. With the rise of wearable electronics, the Internet of Things, and artificial intelligence, healthcare is shifting from a reactive, centralized model to a proactive, personalized, and intelligent one. E-textiles, which are a type of wearable electronics, have revolutionized traditional textiles by incorporating smart features, enabling multifunctional applications. They have made significant progress in personalized healthcare, with applications in disease prevention, real-time health monitoring, and rehabilitation. E-textiles can integrate various sensing mechanisms, including piezoelectric, triboelectric, capacitive, resistive, electrochemical, and thermoelectric effects, to monitor physiological signals such as body movement, heart rate, and sweat composition. These sensors can be embedded in textiles to provide continuous, real-time health monitoring. The development of e-textiles has enabled the creation of smart garments that can detect and respond to various stimuli, including changes in body temperature, pressure, and motion. The materials used in e-textiles include nanofibers, nanomaterials, and nanocomposites, which offer advantages such as high conductivity, flexibility, and durability. These materials are used to create conductive layers, sensors, and other functional components that can be integrated into textiles. The fabrication of e-textiles involves techniques such as electrospinning, solution impregnation, and in-situ polymerization, which allow for the creation of flexible, lightweight, and durable textiles. E-textiles have a wide range of applications in personalized healthcare, including body movement monitoring, sleep state diagnosis, and sweat or body fluid sensing. These applications enable the continuous monitoring of physiological signals, which can be used for early disease diagnosis, personalized treatment, and rehabilitation. The integration of e-textiles with wireless communication devices allows for the creation of wearable medical textile systems that can provide individuals with fast, accurate, and convenient medical care. The future of e-textiles in healthcare is promising, with potential applications in disease prevention, real-time health monitoring, and personalized treatment. The development of e-textiles is expected to continue to advance, with new materials and fabrication techniques being explored to enhance their functionality and performance. The integration of e-textiles with artificial intelligence and machine learning is also expected to play a significant role in the future of personalized healthcare.This review discusses the development of electronic textiles (e-textiles) for personalized, intelligent healthcare. With the rise of wearable electronics, the Internet of Things, and artificial intelligence, healthcare is shifting from a reactive, centralized model to a proactive, personalized, and intelligent one. E-textiles, which are a type of wearable electronics, have revolutionized traditional textiles by incorporating smart features, enabling multifunctional applications. They have made significant progress in personalized healthcare, with applications in disease prevention, real-time health monitoring, and rehabilitation. E-textiles can integrate various sensing mechanisms, including piezoelectric, triboelectric, capacitive, resistive, electrochemical, and thermoelectric effects, to monitor physiological signals such as body movement, heart rate, and sweat composition. These sensors can be embedded in textiles to provide continuous, real-time health monitoring. The development of e-textiles has enabled the creation of smart garments that can detect and respond to various stimuli, including changes in body temperature, pressure, and motion. The materials used in e-textiles include nanofibers, nanomaterials, and nanocomposites, which offer advantages such as high conductivity, flexibility, and durability. These materials are used to create conductive layers, sensors, and other functional components that can be integrated into textiles. The fabrication of e-textiles involves techniques such as electrospinning, solution impregnation, and in-situ polymerization, which allow for the creation of flexible, lightweight, and durable textiles. E-textiles have a wide range of applications in personalized healthcare, including body movement monitoring, sleep state diagnosis, and sweat or body fluid sensing. These applications enable the continuous monitoring of physiological signals, which can be used for early disease diagnosis, personalized treatment, and rehabilitation. The integration of e-textiles with wireless communication devices allows for the creation of wearable medical textile systems that can provide individuals with fast, accurate, and convenient medical care. The future of e-textiles in healthcare is promising, with potential applications in disease prevention, real-time health monitoring, and personalized treatment. The development of e-textiles is expected to continue to advance, with new materials and fabrication techniques being explored to enhance their functionality and performance. The integration of e-textiles with artificial intelligence and machine learning is also expected to play a significant role in the future of personalized healthcare.