This book, edited by Iwao Ojima, explores the role of fluorine in medicinal chemistry and chemical biology. It covers the unique properties of fluorine and its relevance to drug development, with chapters on fluorinated compounds in various therapeutic areas. The book includes topics such as fluorinated prostanoids, inhibitors of matrix metalloproteinases, fluorinated taxoids, and antimalarial agents. It also discusses synthetic methods for fluorinated nucleosides, amino acids, and heteroaromatic systems, as well as the use of fluorine in drug discovery and pharmacology. Chapters on fluorinated amino acids and peptides in chemical biology and protein design are included, along with studies on the effects of fluorination on bioorganic properties and the metabolism of fluorine-containing drugs. The book also includes an appendix with approved pharmaceutical ingredients containing fluorine and sections on fluorine-containing drugs approved by the FDA for human and veterinary use. The book is a comprehensive resource for researchers and professionals in the fields of medicinal chemistry, chemical biology, and pharmaceutical sciences.This book, edited by Iwao Ojima, explores the role of fluorine in medicinal chemistry and chemical biology. It covers the unique properties of fluorine and its relevance to drug development, with chapters on fluorinated compounds in various therapeutic areas. The book includes topics such as fluorinated prostanoids, inhibitors of matrix metalloproteinases, fluorinated taxoids, and antimalarial agents. It also discusses synthetic methods for fluorinated nucleosides, amino acids, and heteroaromatic systems, as well as the use of fluorine in drug discovery and pharmacology. Chapters on fluorinated amino acids and peptides in chemical biology and protein design are included, along with studies on the effects of fluorination on bioorganic properties and the metabolism of fluorine-containing drugs. The book also includes an appendix with approved pharmaceutical ingredients containing fluorine and sections on fluorine-containing drugs approved by the FDA for human and veterinary use. The book is a comprehensive resource for researchers and professionals in the fields of medicinal chemistry, chemical biology, and pharmaceutical sciences.