This book, "Fluorine in Medicinal Chemistry and Chemical Biology," edited by Iwao Ojima, provides a comprehensive overview of the role of fluorine in medicinal chemistry and chemical biology. The content is divided into several sections, each focusing on different aspects of fluorine's applications and synthetic methods. The introduction covers the unique properties of fluorine and their significance in these fields. The subsequent chapters delve into specific applications, including the development of fluorinated prostanoids for anti-glaucoma agents, conformationally restricted glutamate analogues for CNS drug discovery, and fluorinated inhibitors of matrix metalloproteinases. Other chapters discuss fluorinated anticancer agents, antimalarial drugs, and the synthesis of fluorinated nucleosides. The book also explores synthetic methods for creating fluorinated compounds, such as gem-difluoromethylenated nucleosides, fluorinated amino acids, and perfluorinated heteroaromatic systems. It covers the synthesis of drug-like molecules using Fluorous Mixture Synthesis (FMS) and the development of fluorine-18 radiopharmaceuticals. Additionally, the book examines the use of fluorinated amino acids and peptides in chemical biology and pharmacology, including their application in studying protein interactions and membrane-active peptides. The final section focuses on the metabolism of fluorine-containing drugs using in vivo magnetic resonance spectroscopy. The appendix provides a list of approved active pharmaceutical ingredients containing fluorine, both for human and veterinary use in the United States.This book, "Fluorine in Medicinal Chemistry and Chemical Biology," edited by Iwao Ojima, provides a comprehensive overview of the role of fluorine in medicinal chemistry and chemical biology. The content is divided into several sections, each focusing on different aspects of fluorine's applications and synthetic methods. The introduction covers the unique properties of fluorine and their significance in these fields. The subsequent chapters delve into specific applications, including the development of fluorinated prostanoids for anti-glaucoma agents, conformationally restricted glutamate analogues for CNS drug discovery, and fluorinated inhibitors of matrix metalloproteinases. Other chapters discuss fluorinated anticancer agents, antimalarial drugs, and the synthesis of fluorinated nucleosides. The book also explores synthetic methods for creating fluorinated compounds, such as gem-difluoromethylenated nucleosides, fluorinated amino acids, and perfluorinated heteroaromatic systems. It covers the synthesis of drug-like molecules using Fluorous Mixture Synthesis (FMS) and the development of fluorine-18 radiopharmaceuticals. Additionally, the book examines the use of fluorinated amino acids and peptides in chemical biology and pharmacology, including their application in studying protein interactions and membrane-active peptides. The final section focuses on the metabolism of fluorine-containing drugs using in vivo magnetic resonance spectroscopy. The appendix provides a list of approved active pharmaceutical ingredients containing fluorine, both for human and veterinary use in the United States.