The article by Paul W. K. Rothemund describes a method for folding long, single-stranded DNA molecules into arbitrary two-dimensional shapes using a technique called "scaffolded DNA origami." The design process involves raster-filling the desired shape with a 7-kilobase single-stranded scaffold and selecting over 200 short oligonucleotide "staple strands" to hold the scaffold in place. The strands self-assemble in a single step, resulting in structures with a spatial resolution of about 6 nm. These structures can be programmed to bear complex patterns such as words and images. The method has been demonstrated to create various shapes, including squares, triangles, and five-pointed stars, with high yield and complexity. The article also discusses the design process, experimental methods, and potential applications of this technique in fields such as molecular biology and device physics.The article by Paul W. K. Rothemund describes a method for folding long, single-stranded DNA molecules into arbitrary two-dimensional shapes using a technique called "scaffolded DNA origami." The design process involves raster-filling the desired shape with a 7-kilobase single-stranded scaffold and selecting over 200 short oligonucleotide "staple strands" to hold the scaffold in place. The strands self-assemble in a single step, resulting in structures with a spatial resolution of about 6 nm. These structures can be programmed to bear complex patterns such as words and images. The method has been demonstrated to create various shapes, including squares, triangles, and five-pointed stars, with high yield and complexity. The article also discusses the design process, experimental methods, and potential applications of this technique in fields such as molecular biology and device physics.