This study investigates the role of force-induced pyroptosis in orthodontic tooth movement (OTM) and alveolar bone remodeling. Pyroptosis, a form of inflammatory cell death, is regulated by inflammatory caspases and plays a crucial role in maintaining tissue homeostasis and activating inflammatory responses. The study found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling. Blocking or enhancing pyroptosis levels suppressed or promoted OTM and alveolar bone remodeling, respectively. Using *Caspase-1*−/− mice, the study demonstrated that the functional role of force-induced pyroptosis in periodontal ligament (PDL) progenitor cells depended on Caspase-1. Additionally, mechanical force induced pyroptosis in human ex-vivo PDL progenitor cells and in vitro, which influenced osteoclastogenesis. Mechanistically, transient receptor potential subfamily V member 4 (TRPV4) signaling was involved in force-induced Caspase-1-dependent pyroptosis in PDL progenitor cells. Overall, the study suggests a novel mechanism where force-induced pyroptosis in PDL progenitor cells contributes to OTM and alveolar bone remodeling, and targeting Caspase-1-dependent pyroptosis may be a promising approach to accelerate OTM.This study investigates the role of force-induced pyroptosis in orthodontic tooth movement (OTM) and alveolar bone remodeling. Pyroptosis, a form of inflammatory cell death, is regulated by inflammatory caspases and plays a crucial role in maintaining tissue homeostasis and activating inflammatory responses. The study found that mechanical force induced the expression of pyroptosis-related markers in rat OTM and alveolar bone remodeling. Blocking or enhancing pyroptosis levels suppressed or promoted OTM and alveolar bone remodeling, respectively. Using *Caspase-1*−/− mice, the study demonstrated that the functional role of force-induced pyroptosis in periodontal ligament (PDL) progenitor cells depended on Caspase-1. Additionally, mechanical force induced pyroptosis in human ex-vivo PDL progenitor cells and in vitro, which influenced osteoclastogenesis. Mechanistically, transient receptor potential subfamily V member 4 (TRPV4) signaling was involved in force-induced Caspase-1-dependent pyroptosis in PDL progenitor cells. Overall, the study suggests a novel mechanism where force-induced pyroptosis in PDL progenitor cells contributes to OTM and alveolar bone remodeling, and targeting Caspase-1-dependent pyroptosis may be a promising approach to accelerate OTM.