This review examines the role of Per- and Polyfluoroalkyl Substances (PFAS), also known as "forever chemicals," in tribological applications, particularly in lubricants and lubricating systems. PFAS are characterized by their strong C-F bonds and nonpolar nature, which make them highly stable and resistant to environmental degradation. However, their widespread use has led to significant environmental and health concerns. The article discusses the mechanisms by which PFAS are introduced into the environment through lubricants and the subsequent dispersion pathways. It also explores the toxicological implications of PFAS exposure on terrestrial and aquatic life, including plants, animals, and humans, and the ecological consequences of bioaccumulation and biomagnification. Additionally, the review evaluates the regulatory framework governing PFAS applications and potential remediation strategies, including advanced treatment technologies, biodegradation, recovery, and recycling methods, as well as the search for more environmentally benign alternatives. The paper provides a comprehensive overview of PFAS's multifaceted role in tribological applications, highlighting both its benefits and concerns.This review examines the role of Per- and Polyfluoroalkyl Substances (PFAS), also known as "forever chemicals," in tribological applications, particularly in lubricants and lubricating systems. PFAS are characterized by their strong C-F bonds and nonpolar nature, which make them highly stable and resistant to environmental degradation. However, their widespread use has led to significant environmental and health concerns. The article discusses the mechanisms by which PFAS are introduced into the environment through lubricants and the subsequent dispersion pathways. It also explores the toxicological implications of PFAS exposure on terrestrial and aquatic life, including plants, animals, and humans, and the ecological consequences of bioaccumulation and biomagnification. Additionally, the review evaluates the regulatory framework governing PFAS applications and potential remediation strategies, including advanced treatment technologies, biodegradation, recovery, and recycling methods, as well as the search for more environmentally benign alternatives. The paper provides a comprehensive overview of PFAS's multifaceted role in tribological applications, highlighting both its benefits and concerns.