This review explores the role of per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals," in lubrication and their environmental and health impacts. PFAS are highly stable due to their strong C-F bonds and nonpolar nature, making them effective in lubricants and coatings. However, their persistence in the environment and potential toxicity raise concerns. The review covers the classification of PFAS, their manufacturing processes, lubrication mechanisms, and applications in modern automobiles. It also discusses their use in coatings and composite materials, highlighting their tribological properties and environmental risks. The paper addresses the environmental pathways of PFAS through lubrication systems, their toxicological effects on living organisms, and potential remediation strategies. It emphasizes the need for safer alternatives and sustainable practices to mitigate the environmental and health impacts of PFAS. The review concludes with a discussion on the future of PFAS in tribological applications and the importance of balancing their benefits with environmental concerns.This review explores the role of per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals," in lubrication and their environmental and health impacts. PFAS are highly stable due to their strong C-F bonds and nonpolar nature, making them effective in lubricants and coatings. However, their persistence in the environment and potential toxicity raise concerns. The review covers the classification of PFAS, their manufacturing processes, lubrication mechanisms, and applications in modern automobiles. It also discusses their use in coatings and composite materials, highlighting their tribological properties and environmental risks. The paper addresses the environmental pathways of PFAS through lubrication systems, their toxicological effects on living organisms, and potential remediation strategies. It emphasizes the need for safer alternatives and sustainable practices to mitigate the environmental and health impacts of PFAS. The review concludes with a discussion on the future of PFAS in tribological applications and the importance of balancing their benefits with environmental concerns.