This study focuses on the formulation and evaluation of a diclofenac sodium gel, a widely used nonsteroidal anti-inflammatory drug (NSAID) for topical application. The research aims to comprehensively analyze the gel's anti-inflammatory activity, including its mechanism of action, efficacy, safety profile, and clinical applications. Clinical studies have shown significant reductions in pain, swelling, and functional impairment in conditions such as osteoarthritis, rheumatoid arthritis, and soft tissue injuries. The gel's safety profile is generally favorable, with local skin reactions being the most common adverse events. Systemic absorption is low, reducing the risk of gastrointestinal complications and other systemic side effects compared to oral NSAIDs. The study also discusses the formulation and characterization methods, including rheological properties, drug content consistency, in vitro drug release, skin saturation, and microbial testing. The gel's physical appearance, pH, viscosity, spreadability, homogeneity, and stability were evaluated. In vivo studies using a Franz diffusion cell in goat skin were conducted to assess the gel's effectiveness. The results highlight the gel's potential as an effective and safe treatment for localized inflammatory conditions.This study focuses on the formulation and evaluation of a diclofenac sodium gel, a widely used nonsteroidal anti-inflammatory drug (NSAID) for topical application. The research aims to comprehensively analyze the gel's anti-inflammatory activity, including its mechanism of action, efficacy, safety profile, and clinical applications. Clinical studies have shown significant reductions in pain, swelling, and functional impairment in conditions such as osteoarthritis, rheumatoid arthritis, and soft tissue injuries. The gel's safety profile is generally favorable, with local skin reactions being the most common adverse events. Systemic absorption is low, reducing the risk of gastrointestinal complications and other systemic side effects compared to oral NSAIDs. The study also discusses the formulation and characterization methods, including rheological properties, drug content consistency, in vitro drug release, skin saturation, and microbial testing. The gel's physical appearance, pH, viscosity, spreadability, homogeneity, and stability were evaluated. In vivo studies using a Franz diffusion cell in goat skin were conducted to assess the gel's effectiveness. The results highlight the gel's potential as an effective and safe treatment for localized inflammatory conditions.