The study presents the formulation and evaluation of diclofenac sodium transdermal gel, focusing on its anti-inflammatory activity, efficacy, safety, and clinical applications. Diclofenac sodium gel is a widely used non-steroidal anti-inflammatory drug (NSAID) for topical application, targeting local pain and inflammation. It is effective in conditions such as osteoarthritis, rheumatoid arthritis, and soft tissue injuries. The gel's safety profile is generally favorable, with low systemic absorption, reducing the risk of gastrointestinal complications and other systemic side effects associated with oral NSAIDs. However, caution is needed in individuals with a history of hypersensitivity or skin disorders. The formulation of diclofenac gel involves selecting appropriate ingredients, including diclofenac sodium, gelling agents, and preservatives. The study describes the preparation process, including the selection of base materials, gelling agents, and additives. The gel was evaluated for physical appearance, pH, viscosity, spreadability, homogeneity, and stability. Results showed that the gel had good physical properties, with sample F1 exhibiting the highest stability due to its higher viscosity. In-vivo studies were conducted using a Franz diffusion cell to assess the gel's ability to deliver diclofenac into the skin. Stability testing revealed that the gel remained stable under various temperature conditions. The study concludes that diclofenac sodium gel is a promising topical NSAID with notable anti-inflammatory activity, offering targeted delivery and a favorable safety profile. Further research is needed to evaluate its effectiveness in treating inflammation and to explore its potential in broader therapeutic applications. The study also highlights the importance of considering herbal formulations as alternative options for anti-inflammatory and pain-relieving treatments, though their efficacy and safety may vary.The study presents the formulation and evaluation of diclofenac sodium transdermal gel, focusing on its anti-inflammatory activity, efficacy, safety, and clinical applications. Diclofenac sodium gel is a widely used non-steroidal anti-inflammatory drug (NSAID) for topical application, targeting local pain and inflammation. It is effective in conditions such as osteoarthritis, rheumatoid arthritis, and soft tissue injuries. The gel's safety profile is generally favorable, with low systemic absorption, reducing the risk of gastrointestinal complications and other systemic side effects associated with oral NSAIDs. However, caution is needed in individuals with a history of hypersensitivity or skin disorders. The formulation of diclofenac gel involves selecting appropriate ingredients, including diclofenac sodium, gelling agents, and preservatives. The study describes the preparation process, including the selection of base materials, gelling agents, and additives. The gel was evaluated for physical appearance, pH, viscosity, spreadability, homogeneity, and stability. Results showed that the gel had good physical properties, with sample F1 exhibiting the highest stability due to its higher viscosity. In-vivo studies were conducted using a Franz diffusion cell to assess the gel's ability to deliver diclofenac into the skin. Stability testing revealed that the gel remained stable under various temperature conditions. The study concludes that diclofenac sodium gel is a promising topical NSAID with notable anti-inflammatory activity, offering targeted delivery and a favorable safety profile. Further research is needed to evaluate its effectiveness in treating inflammation and to explore its potential in broader therapeutic applications. The study also highlights the importance of considering herbal formulations as alternative options for anti-inflammatory and pain-relieving treatments, though their efficacy and safety may vary.