The study investigates the neurobiological basis of the framing effect, a phenomenon where human choices are significantly influenced by how options are presented. The authors used functional magnetic resonance imaging (fMRI) to examine brain activity during a financial decision-making task. Participants were shown a starting amount of money and then had to choose between a "sure" option and a "gamble" option presented in different frames (Gain or Loss). Behavioral results showed that subjects' choices were strongly affected by the framing manipulation, with risk-averse behavior in the Gain frame and risk-seeking behavior in the Loss frame. fMRI analysis revealed that amygdala activity was significantly higher when subjects' choices aligned with the framing effect, suggesting that emotional processes play a crucial role in mediating decision biases. Additionally, across individuals, orbital and medial prefrontal cortex (OMPFC) activity predicted reduced susceptibility to the framing effect, indicating that more rational individuals have better neural mechanisms for integrating emotional and cognitive information. The findings provide a neurobiological account of the framing effect, highlighting the importance of incorporating emotional processes in models of human choice.The study investigates the neurobiological basis of the framing effect, a phenomenon where human choices are significantly influenced by how options are presented. The authors used functional magnetic resonance imaging (fMRI) to examine brain activity during a financial decision-making task. Participants were shown a starting amount of money and then had to choose between a "sure" option and a "gamble" option presented in different frames (Gain or Loss). Behavioral results showed that subjects' choices were strongly affected by the framing manipulation, with risk-averse behavior in the Gain frame and risk-seeking behavior in the Loss frame. fMRI analysis revealed that amygdala activity was significantly higher when subjects' choices aligned with the framing effect, suggesting that emotional processes play a crucial role in mediating decision biases. Additionally, across individuals, orbital and medial prefrontal cortex (OMPFC) activity predicted reduced susceptibility to the framing effect, indicating that more rational individuals have better neural mechanisms for integrating emotional and cognitive information. The findings provide a neurobiological account of the framing effect, highlighting the importance of incorporating emotional processes in models of human choice.