A study published in *Arch Neurol* (2008) investigated amyloid deposition in elderly individuals without cognitive impairment using Pittsburgh Compound B (PiB) PET imaging. The study included 43 participants aged 65–88 years who did not meet diagnostic criteria for Alzheimer disease (AD) or mild cognitive impairment (MCI). PiB PET imaging was used to assess amyloid deposition, and cognitive function was evaluated using neuropsychological tests. The results showed that 21% of participants had evidence of early amyloid deposition in at least one brain area, as determined by a cutoff value for distribution volume ratio (DVR). There were no significant differences in demographic characteristics or cognitive performance between amyloid-positive and amyloid-negative participants. The study suggests that amyloid deposition can occur in cognitively normal elderly individuals, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic cases. However, amyloid deposition was not associated with worse cognitive function in this group. The findings indicate that some elderly individuals with significant amyloid burden can remain cognitively normal. The study highlights the potential of PiB imaging to identify preclinical Alzheimer disease or to show that amyloid deposition may not be sufficient to cause AD in some individuals. The study also found that amyloid deposition in cognitively unimpaired elderly individuals was primarily in regions that develop heavy amyloid loads in AD patients, such as the anterior cingulate gyrus (ACG) and the precuneus/posterior cingulate gyrus (PRC/PCG). While there was no significant difference in cognitive performance between amyloid-positive and amyloid-negative groups, the amyloid-positive group showed better performance on the Delayed Word Recall test. The study also noted that individuals with the APOE ε4 allele had a higher frequency of amyloid positivity. The study's findings have important implications for future prevention strategies, as they suggest that amyloid accumulation may occur before cognitive symptoms appear. This could allow for early intervention and potentially effective preventative treatments. However, the study's small sample size and need for replication in larger cohorts are limitations. The results emphasize the importance of further research to understand the relationship between amyloid deposition and cognitive function in elderly individuals.A study published in *Arch Neurol* (2008) investigated amyloid deposition in elderly individuals without cognitive impairment using Pittsburgh Compound B (PiB) PET imaging. The study included 43 participants aged 65–88 years who did not meet diagnostic criteria for Alzheimer disease (AD) or mild cognitive impairment (MCI). PiB PET imaging was used to assess amyloid deposition, and cognitive function was evaluated using neuropsychological tests. The results showed that 21% of participants had evidence of early amyloid deposition in at least one brain area, as determined by a cutoff value for distribution volume ratio (DVR). There were no significant differences in demographic characteristics or cognitive performance between amyloid-positive and amyloid-negative participants. The study suggests that amyloid deposition can occur in cognitively normal elderly individuals, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic cases. However, amyloid deposition was not associated with worse cognitive function in this group. The findings indicate that some elderly individuals with significant amyloid burden can remain cognitively normal. The study highlights the potential of PiB imaging to identify preclinical Alzheimer disease or to show that amyloid deposition may not be sufficient to cause AD in some individuals. The study also found that amyloid deposition in cognitively unimpaired elderly individuals was primarily in regions that develop heavy amyloid loads in AD patients, such as the anterior cingulate gyrus (ACG) and the precuneus/posterior cingulate gyrus (PRC/PCG). While there was no significant difference in cognitive performance between amyloid-positive and amyloid-negative groups, the amyloid-positive group showed better performance on the Delayed Word Recall test. The study also noted that individuals with the APOE ε4 allele had a higher frequency of amyloid positivity. The study's findings have important implications for future prevention strategies, as they suggest that amyloid accumulation may occur before cognitive symptoms appear. This could allow for early intervention and potentially effective preventative treatments. However, the study's small sample size and need for replication in larger cohorts are limitations. The results emphasize the importance of further research to understand the relationship between amyloid deposition and cognitive function in elderly individuals.