This review discusses the state of the art in the treatable traits approach for managing chronic respiratory diseases, particularly asthma and COPD. The treatable traits approach is based on identifying characteristics that are susceptible to treatments or predictive of treatment response in individual patients, aiming to accelerate progress in research and clinical practice. The Portraits event, held in Barcelona in 2022, explored key concepts and proposed a novel, comprehensive targeted approach to chronic respiratory disease management. The review highlights the importance of pulmonary, extrapulmonary, and risk factor/behavioural traits, and provides examples of how these traits can be assessed and managed in clinical practice. It also introduces the concept of GETomics, which integrates gene-environment interactions and time to understand the pathogenesis of respiratory diseases. The article concludes with practical suggestions for implementing the treatable traits approach in primary, secondary, and tertiary care settings, emphasizing the need for multidisciplinary teams and financial support.This review discusses the state of the art in the treatable traits approach for managing chronic respiratory diseases, particularly asthma and COPD. The treatable traits approach is based on identifying characteristics that are susceptible to treatments or predictive of treatment response in individual patients, aiming to accelerate progress in research and clinical practice. The Portraits event, held in Barcelona in 2022, explored key concepts and proposed a novel, comprehensive targeted approach to chronic respiratory disease management. The review highlights the importance of pulmonary, extrapulmonary, and risk factor/behavioural traits, and provides examples of how these traits can be assessed and managed in clinical practice. It also introduces the concept of GETomics, which integrates gene-environment interactions and time to understand the pathogenesis of respiratory diseases. The article concludes with practical suggestions for implementing the treatable traits approach in primary, secondary, and tertiary care settings, emphasizing the need for multidisciplinary teams and financial support.