This review discusses the treatable traits approach in managing chronic respiratory diseases, emphasizing its potential for clinical implementation. The treatable traits concept involves identifying characteristics that can be treated or predict treatment response in individual patients, moving towards precision medicine. The Portraits event in Barcelona brought together experts to explore this approach and develop a framework for its application in clinical practice. The review highlights the importance of treatable traits in asthma and COPD, including pulmonary, extrapulmonary, and behavioural traits. It discusses the role of biomarkers such as blood eosinophil count and exhaled nitric oxide in risk stratification and treatment decisions. The NOVELTY study identified 30 treatable traits across chronic respiratory diseases, showing their prevalence and association with diagnostic labels and disease severity. Treatable traits are clinically relevant, impacting outcomes such as exacerbations and quality of life. The review also explores the GETomics approach, which integrates genetic, environmental, and temporal factors to understand disease mechanisms. The implementation of treatable traits in clinical practice requires multidisciplinary teams and tailored interventions. The study emphasizes the need for further research and standardization of diagnostic criteria to improve patient outcomes in chronic respiratory diseases.This review discusses the treatable traits approach in managing chronic respiratory diseases, emphasizing its potential for clinical implementation. The treatable traits concept involves identifying characteristics that can be treated or predict treatment response in individual patients, moving towards precision medicine. The Portraits event in Barcelona brought together experts to explore this approach and develop a framework for its application in clinical practice. The review highlights the importance of treatable traits in asthma and COPD, including pulmonary, extrapulmonary, and behavioural traits. It discusses the role of biomarkers such as blood eosinophil count and exhaled nitric oxide in risk stratification and treatment decisions. The NOVELTY study identified 30 treatable traits across chronic respiratory diseases, showing their prevalence and association with diagnostic labels and disease severity. Treatable traits are clinically relevant, impacting outcomes such as exacerbations and quality of life. The review also explores the GETomics approach, which integrates genetic, environmental, and temporal factors to understand disease mechanisms. The implementation of treatable traits in clinical practice requires multidisciplinary teams and tailored interventions. The study emphasizes the need for further research and standardization of diagnostic criteria to improve patient outcomes in chronic respiratory diseases.