This section provides an overview of the structures of cullin–RING-ligase subunits, complexes, substrates, and regulators. Key references include: 1. **SCF Ubiquitin Ligases:** - **Schulman, B. A. et al.* (2000):** Structure of the Skp1–Skp2 complex. - **Zheng, N. et al.* (2002):** Structure of the Cul1–Rbx1–Skp1–F box^Skp2 SCF ubiquitin ligase complex. - **Orlicky, S. et al.* (2003):** Structural basis for phosphodependent substrate selection and orientation by the SCF^Cdc4 ubiquitin ligase. 2. **Supplementary Information:** - **Wu, G. et al.* (2003):** Structure of a β-TrCP1–Skp1–β-catenin complex. - **Vijay-Kumar, S. et al.* (1987):** Comparison of three-dimensional structures of human, yeast, and oat ubiquitin. - **Cook, W. J. et al.* (1985-1994):** Structures of ubiquitin and related proteins, including tetraubiquitin and diubiquitin conjugate. - **Rao-Naik, C. et al.* (1998):** Crystal structure of *Arabidopsis* rub1 and interactions with NEDD8. - **Whitby, F. G. et al.* (1998):** Crystal structure of NEDD8 and interactions with ubiquitin pathway enzymes. - **Walden, H. et al.* (2003):** Structure of the APPBP1–UBA3–NEDD8–ATP complex and the activating enzyme for NEDD8. - **Ambroggio, X. I. et al.* (2004):** JAMM: A metalloprotease-like zinc site in the proteasome and signalosome. - **Tran, H. J. et al.* (2003):** Structure of the Jab1/MPN domain and its implications for proteasome function. These references collectively provide insights into the structural basis of various components involved in the ubiquitination process, including the SCF ubiquitin ligases, their substrates, and regulatory proteins.This section provides an overview of the structures of cullin–RING-ligase subunits, complexes, substrates, and regulators. Key references include: 1. **SCF Ubiquitin Ligases:** - **Schulman, B. A. et al.* (2000):** Structure of the Skp1–Skp2 complex. - **Zheng, N. et al.* (2002):** Structure of the Cul1–Rbx1–Skp1–F box^Skp2 SCF ubiquitin ligase complex. - **Orlicky, S. et al.* (2003):** Structural basis for phosphodependent substrate selection and orientation by the SCF^Cdc4 ubiquitin ligase. 2. **Supplementary Information:** - **Wu, G. et al.* (2003):** Structure of a β-TrCP1–Skp1–β-catenin complex. - **Vijay-Kumar, S. et al.* (1987):** Comparison of three-dimensional structures of human, yeast, and oat ubiquitin. - **Cook, W. J. et al.* (1985-1994):** Structures of ubiquitin and related proteins, including tetraubiquitin and diubiquitin conjugate. - **Rao-Naik, C. et al.* (1998):** Crystal structure of *Arabidopsis* rub1 and interactions with NEDD8. - **Whitby, F. G. et al.* (1998):** Crystal structure of NEDD8 and interactions with ubiquitin pathway enzymes. - **Walden, H. et al.* (2003):** Structure of the APPBP1–UBA3–NEDD8–ATP complex and the activating enzyme for NEDD8. - **Ambroggio, X. I. et al.* (2004):** JAMM: A metalloprotease-like zinc site in the proteasome and signalosome. - **Tran, H. J. et al.* (2003):** Structure of the Jab1/MPN domain and its implications for proteasome function. These references collectively provide insights into the structural basis of various components involved in the ubiquitination process, including the SCF ubiquitin ligases, their substrates, and regulatory proteins.