This review article focuses on the fabrication, properties, and applications of functional electrospun nanofibers in wound healing. Electrostatic spinning is a versatile technique for producing nanoscale fibers with high specific surface area, porosity, and easy size control, making them suitable for biomedical applications. The review highlights the advantages of functional electrospun nanofibers, such as their biocompatibility, biodegradability, and ease of surface functionalization, which have led to their increasing use in wound healing. The article discusses the structure and healing mechanisms of skin and wound healing, emphasizing the four phases: hemostasis, inflammation, proliferation, and remodeling. It reviews the development of functional electrospun nanofiber dressings with various functionalities, including antimicrobial, anti-inflammatory, hemostatic, antioxidant, controlled drug release, responsiveness, exudate management, and wound monitoring. Key advancements in the field are highlighted, such as the use of antimicrobial metal nanoparticles (e.g., zinc oxide, silver) and natural antioxidants (e.g., polyphenols) to enhance the antibacterial and anti-inflammatory properties of nanofibers. The article also explores the potential of nanofibers for drug delivery and controlled release, including the use of sequential, synchronized, coaxial, and side-by-side electrospinning techniques. Additionally, the review discusses self-healing and stimuli-responsive nanofibers, which can repair themselves or respond to external stimuli like temperature, pH, and light. These materials can promote wound healing by controlling the release of bioactive substances and enhancing tissue regeneration. Overall, the article provides a comprehensive overview of the current state of functional electrospun nanofiber dressings and their potential in advancing wound healing and tissue engineering.This review article focuses on the fabrication, properties, and applications of functional electrospun nanofibers in wound healing. Electrostatic spinning is a versatile technique for producing nanoscale fibers with high specific surface area, porosity, and easy size control, making them suitable for biomedical applications. The review highlights the advantages of functional electrospun nanofibers, such as their biocompatibility, biodegradability, and ease of surface functionalization, which have led to their increasing use in wound healing. The article discusses the structure and healing mechanisms of skin and wound healing, emphasizing the four phases: hemostasis, inflammation, proliferation, and remodeling. It reviews the development of functional electrospun nanofiber dressings with various functionalities, including antimicrobial, anti-inflammatory, hemostatic, antioxidant, controlled drug release, responsiveness, exudate management, and wound monitoring. Key advancements in the field are highlighted, such as the use of antimicrobial metal nanoparticles (e.g., zinc oxide, silver) and natural antioxidants (e.g., polyphenols) to enhance the antibacterial and anti-inflammatory properties of nanofibers. The article also explores the potential of nanofibers for drug delivery and controlled release, including the use of sequential, synchronized, coaxial, and side-by-side electrospinning techniques. Additionally, the review discusses self-healing and stimuli-responsive nanofibers, which can repair themselves or respond to external stimuli like temperature, pH, and light. These materials can promote wound healing by controlling the release of bioactive substances and enhancing tissue regeneration. Overall, the article provides a comprehensive overview of the current state of functional electrospun nanofiber dressings and their potential in advancing wound healing and tissue engineering.