Functional electrospun nanofibers have gained significant attention due to their versatility, simplicity, and ability to be functionalized. These nanofibers are used in biomedical applications, particularly in wound healing, due to their high surface area, porosity, and biocompatibility. They offer advantages such as easy size control, surface functionalization, and the ability to be tailored for specific functions like antimicrobial, anti-inflammatory, hemostatic, antioxidant, and controlled drug release. Recent studies have shown that functional electrospun nanofibers can enhance wound healing by promoting tissue regeneration, reducing inflammation, and preventing infections. They are also used in the development of advanced materials for biomedical applications, including scaffolds for tissue engineering and smart packaging. The electrospinning process involves creating nanofibers through high-voltage electrostatic forces, and various techniques such as dry, wet, coaxial, and bubble spinning are used to produce these fibers. Parameters such as solution concentration, voltage, and environmental conditions affect the morphology and properties of the nanofibers. The application of functional electrospun nanofibers in wound healing includes the use of antimicrobial agents, antioxidants, and drug delivery systems to promote healing and prevent complications. These nanofibers have shown promise in treating various types of wounds, including acute and chronic wounds, and are being explored for their potential in biomedical applications. The review highlights the importance of functional modification of nanofibers to enhance their properties and effectiveness in wound healing, as well as the need for further research to optimize their use in clinical settings.Functional electrospun nanofibers have gained significant attention due to their versatility, simplicity, and ability to be functionalized. These nanofibers are used in biomedical applications, particularly in wound healing, due to their high surface area, porosity, and biocompatibility. They offer advantages such as easy size control, surface functionalization, and the ability to be tailored for specific functions like antimicrobial, anti-inflammatory, hemostatic, antioxidant, and controlled drug release. Recent studies have shown that functional electrospun nanofibers can enhance wound healing by promoting tissue regeneration, reducing inflammation, and preventing infections. They are also used in the development of advanced materials for biomedical applications, including scaffolds for tissue engineering and smart packaging. The electrospinning process involves creating nanofibers through high-voltage electrostatic forces, and various techniques such as dry, wet, coaxial, and bubble spinning are used to produce these fibers. Parameters such as solution concentration, voltage, and environmental conditions affect the morphology and properties of the nanofibers. The application of functional electrospun nanofibers in wound healing includes the use of antimicrobial agents, antioxidants, and drug delivery systems to promote healing and prevent complications. These nanofibers have shown promise in treating various types of wounds, including acute and chronic wounds, and are being explored for their potential in biomedical applications. The review highlights the importance of functional modification of nanofibers to enhance their properties and effectiveness in wound healing, as well as the need for further research to optimize their use in clinical settings.