Clinoptilolite, a natural zeolite, is widely available and has versatile physico-chemical properties that make it suitable for various sustainable applications. It is used in environmental catalysis, CO₂ removal, wastewater treatment, aquaculture, animal feeding, the food industry, medical applications, and energy storage systems. Its framework allows for the tuning of material features, enabling it to adsorb specific compounds. This review aims to explore the diverse applications of clinoptilolite, emphasizing its sustainability, cost-effectiveness, and non-harmfulness to humans and animals. The review also promotes the use of natural materials to reduce chemical usage and environmental impact. Clinoptilolite is formed in various geological environments, including marine pyroclastic and volcaniclastic sequences, and is found in calcareous soils, deep-sea sediments, and volcanic areas. It has a unique structure with interconnected channels and cavities, allowing for the adsorption of water and cations. The material's properties, such as its high thermal stability and cation exchange capacity, make it suitable for various applications. The Si/Al ratio influences its properties, with higher ratios leading to greater hydrophobicity and lower cation exchange capacity. Clinoptilolite exhibits ion exchange properties, allowing it to exchange ions and modify its selectivity towards specific compounds. It is also effective in water adsorption and desorption, making it useful for thermal energy storage. The material's ability to adsorb and desorb water cyclically is a key advantage for thermal energy storage applications. Clinoptilolite has been extensively used in environmental remediation, particularly for its ion-exchange properties. It is effective in the separation, binding, and chemical stabilization of hazardous species in soils and aqueous systems. It is also used in the removal of pollutants from gas streams, such as carbon dioxide, methane, and ammonia. Its affinity for water makes it suitable for removing moisture and impurities from gases, acting as a desiccant in air conditioning systems and natural gas drying. Clinoptilolite's low cost, high availability, and good mechanical and thermal properties make it a promising material for various applications. Its high adsorption capacity and sustainability make it an attractive alternative to synthetic materials. The review highlights the potential of clinoptilolite in various fields, including pollution control, catalysis, and agriculture, and emphasizes the importance of using natural materials to reduce environmental impact.Clinoptilolite, a natural zeolite, is widely available and has versatile physico-chemical properties that make it suitable for various sustainable applications. It is used in environmental catalysis, CO₂ removal, wastewater treatment, aquaculture, animal feeding, the food industry, medical applications, and energy storage systems. Its framework allows for the tuning of material features, enabling it to adsorb specific compounds. This review aims to explore the diverse applications of clinoptilolite, emphasizing its sustainability, cost-effectiveness, and non-harmfulness to humans and animals. The review also promotes the use of natural materials to reduce chemical usage and environmental impact. Clinoptilolite is formed in various geological environments, including marine pyroclastic and volcaniclastic sequences, and is found in calcareous soils, deep-sea sediments, and volcanic areas. It has a unique structure with interconnected channels and cavities, allowing for the adsorption of water and cations. The material's properties, such as its high thermal stability and cation exchange capacity, make it suitable for various applications. The Si/Al ratio influences its properties, with higher ratios leading to greater hydrophobicity and lower cation exchange capacity. Clinoptilolite exhibits ion exchange properties, allowing it to exchange ions and modify its selectivity towards specific compounds. It is also effective in water adsorption and desorption, making it useful for thermal energy storage. The material's ability to adsorb and desorb water cyclically is a key advantage for thermal energy storage applications. Clinoptilolite has been extensively used in environmental remediation, particularly for its ion-exchange properties. It is effective in the separation, binding, and chemical stabilization of hazardous species in soils and aqueous systems. It is also used in the removal of pollutants from gas streams, such as carbon dioxide, methane, and ammonia. Its affinity for water makes it suitable for removing moisture and impurities from gases, acting as a desiccant in air conditioning systems and natural gas drying. Clinoptilolite's low cost, high availability, and good mechanical and thermal properties make it a promising material for various applications. Its high adsorption capacity and sustainability make it an attractive alternative to synthetic materials. The review highlights the potential of clinoptilolite in various fields, including pollution control, catalysis, and agriculture, and emphasizes the importance of using natural materials to reduce environmental impact.