The book "Fundamentals of Clinical Trials" (Fourth Edition) by Lawrence M. Friedman, Curt D. Furborg, and David L. DeMets provides a comprehensive guide to the design, conduct, analysis, and reporting of clinical trials. The authors aim to improve the quality of clinical trials by discussing fundamental concepts and providing examples from their extensive experience. The book covers various aspects of clinical trials, including ethical issues, study design, randomization, sample size estimation, data collection, adverse event assessment, quality of life evaluation, participant adherence, survival analysis, data monitoring, and reporting of results. It also addresses the challenges and considerations in multicenter and multinational studies. The book is intended for investigators with some clinical trial experience and those planning their first trial, as well as for teaching purposes and for members of the scientific and medical community who need to evaluate and interpret published trial reports. The authors emphasize the importance of adhering to fundamental principles to ensure the validity and reliability of clinical trials.The book "Fundamentals of Clinical Trials" (Fourth Edition) by Lawrence M. Friedman, Curt D. Furborg, and David L. DeMets provides a comprehensive guide to the design, conduct, analysis, and reporting of clinical trials. The authors aim to improve the quality of clinical trials by discussing fundamental concepts and providing examples from their extensive experience. The book covers various aspects of clinical trials, including ethical issues, study design, randomization, sample size estimation, data collection, adverse event assessment, quality of life evaluation, participant adherence, survival analysis, data monitoring, and reporting of results. It also addresses the challenges and considerations in multicenter and multinational studies. The book is intended for investigators with some clinical trial experience and those planning their first trial, as well as for teaching purposes and for members of the scientific and medical community who need to evaluate and interpret published trial reports. The authors emphasize the importance of adhering to fundamental principles to ensure the validity and reliability of clinical trials.