Fusarium species are common plant pathogens that can cause infections in humans, particularly in immunocompromised patients. These infections range from superficial to invasive and disseminated forms, with the latter being more common in severely immunocompromised individuals. Fusarium species are widespread in the environment, including soil, water, and plant material, and can cause a variety of infections, such as keratitis, onychomycosis, sinusitis, pneumonia, and fungemia. The clinical manifestations depend on the portal of entry and the patient's immune status. Fusarium infections are often difficult to diagnose and treat, with high mortality rates in immunocompromised patients. Diagnosis typically involves clinical evaluation, culture, and molecular techniques. Treatment options include antifungal agents such as amphotericin B, voriconazole, and posaconazole, often in combination with immunotherapy. Prevention strategies focus on reducing exposure to Fusarium species and managing immunosuppression in high-risk patients. The prognosis is poor for disseminated fusariosis, with high mortality rates, especially in patients with prolonged neutropenia. Effective treatment requires early diagnosis and aggressive antifungal therapy.Fusarium species are common plant pathogens that can cause infections in humans, particularly in immunocompromised patients. These infections range from superficial to invasive and disseminated forms, with the latter being more common in severely immunocompromised individuals. Fusarium species are widespread in the environment, including soil, water, and plant material, and can cause a variety of infections, such as keratitis, onychomycosis, sinusitis, pneumonia, and fungemia. The clinical manifestations depend on the portal of entry and the patient's immune status. Fusarium infections are often difficult to diagnose and treat, with high mortality rates in immunocompromised patients. Diagnosis typically involves clinical evaluation, culture, and molecular techniques. Treatment options include antifungal agents such as amphotericin B, voriconazole, and posaconazole, often in combination with immunotherapy. Prevention strategies focus on reducing exposure to Fusarium species and managing immunosuppression in high-risk patients. The prognosis is poor for disseminated fusariosis, with high mortality rates, especially in patients with prolonged neutropenia. Effective treatment requires early diagnosis and aggressive antifungal therapy.