Author:Zefang Tang, Boxi Kang, Chenwei Li, Tianxiang Chen, Zemin Zhang
Pages:5
Summary:GEPIA2 is an enhanced version of the GEPIA web server, introduced in 2017, which has been widely used for gene expression analysis based on tumor and normal samples from the TCGA and GTEx databases. GEPIA2 offers several new features and improvements, including:
1. **Isoform Level Analysis**: GEPIA2 extends gene expression quantification from the gene level to the transcript level, providing 198,619 isoforms and supporting analysis at the isoform level.
2. **Cancer Subtype Analysis**: Users can analyze specific cancer subtypes and compare them, with support for 84 cancer subtypes.
3. **Gene Signature Quantification**: Inspired by single-cell sequencing studies, GEPIA2 incorporates new analysis techniques for gene signature quantification.
4. **Custom Data Analysis**: Users can upload their own RNA-seq data and compare it with TCGA and GTEx samples.
5. **API for Batch Processing**: An API is provided for batch processing and easy retrieval of analysis results.
The web server is publicly accessible at http://gepia2.cancer-pku.cn/ and is designed to facilitate interactive and intuitive exploration of large-scale gene expression datasets. The new features and improvements in GEPIA2 allow researchers to perform more detailed and nuanced analyses, making it a valuable tool for experimental biologists and clinicians.