Gelatin-based biomaterials and gelatin as an additive for chronic wound repair. Front. Pharmacol. 15:1398939. doi: 10.3389/fphar.2024.1398939 Gelatin, derived from natural collagen, is widely used in biomedical applications due to its biocompatibility, degradability, and availability. However, it has limitations in antibacterial activity and mechanical properties. This review discusses the role of gelatin-based biomaterials in chronic wound healing, focusing on hemostasis, antibacterial properties, anti-inflammatory effects, vascular regeneration, and epidermal regeneration. Gelatin-based materials such as hydrogels, sponges, and dressings have shown promise in promoting wound healing by enhancing hemostasis, reducing infection, and supporting tissue regeneration. The review also highlights the challenges in improving gelatin's properties and the potential of gelatin-based materials in future wound healing applications. Clinical applications of gelatin-based materials have been demonstrated in various wound healing scenarios, and ongoing research aims to enhance their efficiency and effectiveness in treating chronic wounds. Despite progress, challenges remain in optimizing gelatin-based materials for widespread clinical use.Gelatin-based biomaterials and gelatin as an additive for chronic wound repair. Front. Pharmacol. 15:1398939. doi: 10.3389/fphar.2024.1398939 Gelatin, derived from natural collagen, is widely used in biomedical applications due to its biocompatibility, degradability, and availability. However, it has limitations in antibacterial activity and mechanical properties. This review discusses the role of gelatin-based biomaterials in chronic wound healing, focusing on hemostasis, antibacterial properties, anti-inflammatory effects, vascular regeneration, and epidermal regeneration. Gelatin-based materials such as hydrogels, sponges, and dressings have shown promise in promoting wound healing by enhancing hemostasis, reducing infection, and supporting tissue regeneration. The review also highlights the challenges in improving gelatin's properties and the potential of gelatin-based materials in future wound healing applications. Clinical applications of gelatin-based materials have been demonstrated in various wound healing scenarios, and ongoing research aims to enhance their efficiency and effectiveness in treating chronic wounds. Despite progress, challenges remain in optimizing gelatin-based materials for widespread clinical use.