The article reviews the use of gelatin-based biomaterials and gelatin as additives in chronic wound repair. Chronic wounds, characterized by prolonged healing times, increased infection, and poor oxygen flow, are a significant healthcare burden. Gelatin, derived from collagen, is widely used in biomedical fields due to its low cost, biocompatibility, and degradability. However, it exhibits poor antibacterial activity and mechanical properties. Research has focused on enhancing these properties to improve chronic wound healing. Gelatin-based biomaterials, such as sponges, hydrogels, and dressings, promote hemostasis, enhance antibacterial and anti-inflammatory properties, and stimulate vascular and epithelial cell regeneration. The article discusses the natural process of wound healing, the role of gelatin-based materials, and future implications. Key applications include hemostatic materials, antibacterial agents, anti-inflammatory agents, and promoters of vascular and epithelial regeneration. Clinical applications of gelatin hemostatic sponges are highlighted, along with the potential of 3D printing technology in preparing gelatin scaffolds. Despite progress, challenges remain, and large-scale clinical trials are needed to verify the effectiveness of gelatin-based biomaterials.The article reviews the use of gelatin-based biomaterials and gelatin as additives in chronic wound repair. Chronic wounds, characterized by prolonged healing times, increased infection, and poor oxygen flow, are a significant healthcare burden. Gelatin, derived from collagen, is widely used in biomedical fields due to its low cost, biocompatibility, and degradability. However, it exhibits poor antibacterial activity and mechanical properties. Research has focused on enhancing these properties to improve chronic wound healing. Gelatin-based biomaterials, such as sponges, hydrogels, and dressings, promote hemostasis, enhance antibacterial and anti-inflammatory properties, and stimulate vascular and epithelial cell regeneration. The article discusses the natural process of wound healing, the role of gelatin-based materials, and future implications. Key applications include hemostatic materials, antibacterial agents, anti-inflammatory agents, and promoters of vascular and epithelial regeneration. Clinical applications of gelatin hemostatic sponges are highlighted, along with the potential of 3D printing technology in preparing gelatin scaffolds. Despite progress, challenges remain, and large-scale clinical trials are needed to verify the effectiveness of gelatin-based biomaterials.