This study investigates gender differences in the severity and mortality of patients with COVID-19 and SARS. The researchers analyzed data from a case series of 43 hospitalized COVID-19 patients, a public dataset of 37 deceased and 1,019 surviving COVID-19 patients, and data from 524 SARS patients. Key findings include: 1. **Older Age and Comorbidities**: Both COVID-19 and SARS patients with older age and more comorbidities had higher severity and mortality. 2. **Gender Differences in COVID-19**: In the case series, men's cases tended to be more severe (P = 0.035). In the public dataset, men had a 2.4 times higher mortality rate compared to women (70.3% vs. 29.7%, P = 0.016). 3. **SARS Patients**: In the SARS dataset, men also had a higher mortality rate (P = 0.015). The study concludes that while men and women have similar prevalence rates of COVID-19, men are more at risk for worse outcomes and death, independent of age. This preliminary study highlights the need for further research on gender-specific prognostic factors in COVID-19.This study investigates gender differences in the severity and mortality of patients with COVID-19 and SARS. The researchers analyzed data from a case series of 43 hospitalized COVID-19 patients, a public dataset of 37 deceased and 1,019 surviving COVID-19 patients, and data from 524 SARS patients. Key findings include: 1. **Older Age and Comorbidities**: Both COVID-19 and SARS patients with older age and more comorbidities had higher severity and mortality. 2. **Gender Differences in COVID-19**: In the case series, men's cases tended to be more severe (P = 0.035). In the public dataset, men had a 2.4 times higher mortality rate compared to women (70.3% vs. 29.7%, P = 0.016). 3. **SARS Patients**: In the SARS dataset, men also had a higher mortality rate (P = 0.015). The study concludes that while men and women have similar prevalence rates of COVID-19, men are more at risk for worse outcomes and death, independent of age. This preliminary study highlights the need for further research on gender-specific prognostic factors in COVID-19.