GeneMANIA (http://genemania.org) is a user-friendly web tool for generating hypotheses about gene function, analyzing gene lists, and prioritizing genes for functional assays. It supports nine organisms and integrates data from various sources, including GEO, BioGRID, iRefindex, and I2D. The tool can predict gene functions based on single or multiple gene queries and network searches. Recent updates include the addition of zebrafish and E. coli data, a redesigned user interface with improved visualization and usability, enhanced query handling, and integration with the Cytoscape desktop software. The tool now supports gestures and shortcut keys, query history, and PDF report generation. Future plans include further improvements to the user interface and data sources.GeneMANIA (http://genemania.org) is a user-friendly web tool for generating hypotheses about gene function, analyzing gene lists, and prioritizing genes for functional assays. It supports nine organisms and integrates data from various sources, including GEO, BioGRID, iRefindex, and I2D. The tool can predict gene functions based on single or multiple gene queries and network searches. Recent updates include the addition of zebrafish and E. coli data, a redesigned user interface with improved visualization and usability, enhanced query handling, and integration with the Cytoscape desktop software. The tool now supports gestures and shortcut keys, query history, and PDF report generation. Future plans include further improvements to the user interface and data sources.