The World Health Organization (WHO) has developed guidelines for research and evaluation of traditional medicine, acknowledging the contributions of over 100 experts and national health authorities. These guidelines aim to improve the quality and value of research in traditional medicine by providing standards, technical guidance, and information on safety, efficacy, and quality control. The guidelines cover methodologies for research and evaluation of herbal medicines and traditional procedure-based therapies, as well as clinical research, ethics, education, and surveillance systems. They emphasize the importance of ensuring the safety and efficacy of traditional medicine while respecting its holistic approach and cultural context. The guidelines also recommend the use of the WHO QOL user manual for evaluating the results of clinical research in traditional medicine. The guidelines are intended to serve as a reference for researchers, healthcare providers, manufacturers, traders, and health authorities. They are based on the principles of ensuring the safety and efficacy of traditional medicine while not hindering its application and development. The guidelines are intended to be revised in the future to respond to developments in research on traditional medicine. The guidelines are available in English and are intended to be used by WHO Member States. The guidelines are based on the principles of ensuring the safety and efficacy of traditional medicine while not hindering its application and development. The guidelines are intended to be revised in the future to respond to developments in research on traditional medicine.The World Health Organization (WHO) has developed guidelines for research and evaluation of traditional medicine, acknowledging the contributions of over 100 experts and national health authorities. These guidelines aim to improve the quality and value of research in traditional medicine by providing standards, technical guidance, and information on safety, efficacy, and quality control. The guidelines cover methodologies for research and evaluation of herbal medicines and traditional procedure-based therapies, as well as clinical research, ethics, education, and surveillance systems. They emphasize the importance of ensuring the safety and efficacy of traditional medicine while respecting its holistic approach and cultural context. The guidelines also recommend the use of the WHO QOL user manual for evaluating the results of clinical research in traditional medicine. The guidelines are intended to serve as a reference for researchers, healthcare providers, manufacturers, traders, and health authorities. They are based on the principles of ensuring the safety and efficacy of traditional medicine while not hindering its application and development. The guidelines are intended to be revised in the future to respond to developments in research on traditional medicine. The guidelines are available in English and are intended to be used by WHO Member States. The guidelines are based on the principles of ensuring the safety and efficacy of traditional medicine while not hindering its application and development. The guidelines are intended to be revised in the future to respond to developments in research on traditional medicine.