The document provides general guidelines for methodologies on research and evaluation of traditional medicine, developed by the World Health Organization (WHO). It acknowledges the contributions of over 100 experts and national health authorities, as well as the support from various organizations. The guidelines aim to harmonize terminology, improve the quality and value of research, and provide appropriate evaluation methods for traditional medicine. They cover herbal medicines and traditional procedure-based therapies, emphasizing the importance of botanical verification, quality control, safety, and efficacy. The document outlines specific methodologies for research, including literature reviews, study design, and ethical considerations. It also addresses pragmatic issues such as funding, training, and surveillance systems. The guidelines are intended to serve as a reference for researchers, healthcare providers, manufacturers, traders, and health authorities.The document provides general guidelines for methodologies on research and evaluation of traditional medicine, developed by the World Health Organization (WHO). It acknowledges the contributions of over 100 experts and national health authorities, as well as the support from various organizations. The guidelines aim to harmonize terminology, improve the quality and value of research, and provide appropriate evaluation methods for traditional medicine. They cover herbal medicines and traditional procedure-based therapies, emphasizing the importance of botanical verification, quality control, safety, and efficacy. The document outlines specific methodologies for research, including literature reviews, study design, and ethical considerations. It also addresses pragmatic issues such as funding, training, and surveillance systems. The guidelines are intended to serve as a reference for researchers, healthcare providers, manufacturers, traders, and health authorities.