This study presents a method to generate dual structurally and functionally skin-mimicking hydrogels by crosslinking cell-membrane compartments. The hydrogels are formed through free radical polymerization using olefinic double bond-functionalized extracellular vesicles as crosslinkers, which enhance mechanical strength compared to traditional hydrogels. These hydrogels exhibit antibacterial activity and promote dendritic cell maturation and activation due to the presence of bioactive substances in the extracellular vesicles. The versatility of this approach is demonstrated by introducing a second network through a catalyst-free click reaction, allowing for the tuning of both structure and function. This biomimetic paradigm opens up new avenues for developing advanced skin-inspired biomaterials.This study presents a method to generate dual structurally and functionally skin-mimicking hydrogels by crosslinking cell-membrane compartments. The hydrogels are formed through free radical polymerization using olefinic double bond-functionalized extracellular vesicles as crosslinkers, which enhance mechanical strength compared to traditional hydrogels. These hydrogels exhibit antibacterial activity and promote dendritic cell maturation and activation due to the presence of bioactive substances in the extracellular vesicles. The versatility of this approach is demonstrated by introducing a second network through a catalyst-free click reaction, allowing for the tuning of both structure and function. This biomimetic paradigm opens up new avenues for developing advanced skin-inspired biomaterials.