The article presents the genome sequence of *Phanerochaete chrysosporium* strain RP78, a white rot fungus capable of degrading lignocellulose. The 30-million base-pair genome was sequenced using a whole-genome shotgun approach, revealing an extensive array of genes encoding secreted oxidases, peroxidases, and hydrolytic enzymes. The genome includes 11,777 predicted protein-coding genes, with 72.1% showing significant sequence similarity to known proteins. The study highlights the genetic repertoire of white rot fungi, which are crucial for understanding lignocellulose degradation and its applications in biotechnology. The genome also contains numerous repetitive elements and mobile elements, and the authors discuss the potential roles of these in gene expression and evolution. The findings contribute to the broader understanding of fungal biology and the global carbon cycle.The article presents the genome sequence of *Phanerochaete chrysosporium* strain RP78, a white rot fungus capable of degrading lignocellulose. The 30-million base-pair genome was sequenced using a whole-genome shotgun approach, revealing an extensive array of genes encoding secreted oxidases, peroxidases, and hydrolytic enzymes. The genome includes 11,777 predicted protein-coding genes, with 72.1% showing significant sequence similarity to known proteins. The study highlights the genetic repertoire of white rot fungi, which are crucial for understanding lignocellulose degradation and its applications in biotechnology. The genome also contains numerous repetitive elements and mobile elements, and the authors discuss the potential roles of these in gene expression and evolution. The findings contribute to the broader understanding of fungal biology and the global carbon cycle.