The article explores the emerging field of geroscience, which examines the relationship between aging and age-related diseases. It highlights the importance of understanding the cellular and molecular mechanisms underlying aging, such as mitochondrial dysfunction, cellular senescence, and genomic instability, in the context of pathology. The paper discusses how these mechanisms contribute to the development of diseases like cardiovascular disease, cancer, and neurodegenerative disorders. It emphasizes the role of key biomarkers of aging and biological age in pathology, and the significance of assessing these factors in understanding disease progression. The article also reviews the interplay between cellular senescence and cancer biology, and the potential of anti-aging interventions such as senolytics, mitochondrial-targeted treatments, and epigenetic regulation modulators in combating age-related diseases. The integration of geroscience concepts into pathology research is seen as a transformative shift that could lead to breakthroughs in disease prevention and treatment. The paper also discusses the use of age-relevant disease models in pathology, the development of novel tools and models from geroscience, and the importance of epigenetic clocks in assessing biological age. The study concludes that geroscience offers a new perspective for pathology, bridging the gap between aging processes and disease pathogenesis, and has the potential to revolutionize our understanding of disease mechanisms and improve treatment strategies for age-related conditions.The article explores the emerging field of geroscience, which examines the relationship between aging and age-related diseases. It highlights the importance of understanding the cellular and molecular mechanisms underlying aging, such as mitochondrial dysfunction, cellular senescence, and genomic instability, in the context of pathology. The paper discusses how these mechanisms contribute to the development of diseases like cardiovascular disease, cancer, and neurodegenerative disorders. It emphasizes the role of key biomarkers of aging and biological age in pathology, and the significance of assessing these factors in understanding disease progression. The article also reviews the interplay between cellular senescence and cancer biology, and the potential of anti-aging interventions such as senolytics, mitochondrial-targeted treatments, and epigenetic regulation modulators in combating age-related diseases. The integration of geroscience concepts into pathology research is seen as a transformative shift that could lead to breakthroughs in disease prevention and treatment. The paper also discusses the use of age-relevant disease models in pathology, the development of novel tools and models from geroscience, and the importance of epigenetic clocks in assessing biological age. The study concludes that geroscience offers a new perspective for pathology, bridging the gap between aging processes and disease pathogenesis, and has the potential to revolutionize our understanding of disease mechanisms and improve treatment strategies for age-related conditions.