Wegener's granulomatosis is a rare syndrome characterized by progressive ulceration in the respiratory tract and widespread inflammatory disease. The disease typically affects young to middle-aged adults, with insidious onset and non-specific respiratory symptoms. Two main patterns of initial symptoms are observed: persistent purulent rhinorrhoea and nasal obstruction, or chronic cough, hemoptysis, and pleurisy. The course is rapid, often leading to death within five months, though some cases have shown remission periods. Key features include extensive ulceration in the respiratory tract, widespread granulomatous lesions, and vascular necrosis. The initial lesion is granulomatous inflammation in the respiratory tract, which may spread to involve the lungs, kidneys, and spleen. Treatment focuses on healing the initial lesion with radiotherapy and controlling secondary infections, while steroids are used for widespread lesions. The disease is distinct from other conditions like polyarteritis nodosa and malignant granuloma, and its pathogenesis is believed to involve a hypersensitivity reaction.Wegener's granulomatosis is a rare syndrome characterized by progressive ulceration in the respiratory tract and widespread inflammatory disease. The disease typically affects young to middle-aged adults, with insidious onset and non-specific respiratory symptoms. Two main patterns of initial symptoms are observed: persistent purulent rhinorrhoea and nasal obstruction, or chronic cough, hemoptysis, and pleurisy. The course is rapid, often leading to death within five months, though some cases have shown remission periods. Key features include extensive ulceration in the respiratory tract, widespread granulomatous lesions, and vascular necrosis. The initial lesion is granulomatous inflammation in the respiratory tract, which may spread to involve the lungs, kidneys, and spleen. Treatment focuses on healing the initial lesion with radiotherapy and controlling secondary infections, while steroids are used for widespread lesions. The disease is distinct from other conditions like polyarteritis nodosa and malignant granuloma, and its pathogenesis is believed to involve a hypersensitivity reaction.