This systematic review and meta-analysis aimed to determine the global prevalence of chronic kidney disease (CKD) by stage, geographical location, gender, and age. The study included 100 observational studies with a total of 6,908,440 patients from 112 populations. The global mean (95% CI) prevalence of CKD across all five stages was 13.4% (11.7–15.1%), and for stages 3–5, it was 10.6% (9.2–12.2%). The prevalence was higher in women than in men, with a mean prevalence of 14.6% (12.7–16.7%) in women and 12.8% (10.8–14.9%) in men. The study also found that CKD prevalence increased with age, and developed regions had higher rates compared to developing regions. The authors concluded that CKD is a significant global health burden, with a high economic cost to health systems, and recommended future research to evaluate intervention strategies to delay CKD progression and improve cardiovascular disease outcomes.This systematic review and meta-analysis aimed to determine the global prevalence of chronic kidney disease (CKD) by stage, geographical location, gender, and age. The study included 100 observational studies with a total of 6,908,440 patients from 112 populations. The global mean (95% CI) prevalence of CKD across all five stages was 13.4% (11.7–15.1%), and for stages 3–5, it was 10.6% (9.2–12.2%). The prevalence was higher in women than in men, with a mean prevalence of 14.6% (12.7–16.7%) in women and 12.8% (10.8–14.9%) in men. The study also found that CKD prevalence increased with age, and developed regions had higher rates compared to developing regions. The authors concluded that CKD is a significant global health burden, with a high economic cost to health systems, and recommended future research to evaluate intervention strategies to delay CKD progression and improve cardiovascular disease outcomes.