The article reviews the global prevalence and incidence of several serious fungal diseases, including chronic pulmonary aspergillosis, invasive candidiasis, invasive aspergillosis, pneumocystis jirovecii pneumonia, allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization, fungal keratitis, and recurrent vulvovaginal candidiasis. It highlights the limitations of current diagnostic methods and the need for improved surveillance and treatment. The Leading International Fungal Education (LIFE) portal has facilitated country-specific estimates for over 5.7 billion people, but these estimates are subject to biases and underreporting. The article emphasizes the importance of early diagnosis and prompt antifungal therapy to reduce mortality and improve patient outcomes.The article reviews the global prevalence and incidence of several serious fungal diseases, including chronic pulmonary aspergillosis, invasive candidiasis, invasive aspergillosis, pneumocystis jirovecii pneumonia, allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization, fungal keratitis, and recurrent vulvovaginal candidiasis. It highlights the limitations of current diagnostic methods and the need for improved surveillance and treatment. The Leading International Fungal Education (LIFE) portal has facilitated country-specific estimates for over 5.7 billion people, but these estimates are subject to biases and underreporting. The article emphasizes the importance of early diagnosis and prompt antifungal therapy to reduce mortality and improve patient outcomes.