The study evaluates the global burden of gynecological cancers (GCs) in 2022 and projects future trends up to 2050. In 2022, there were 1,473,427 new cases and 680,372 deaths from GCs, with significant regional disparities. Eastern Africa had the highest incidence and mortality rates, while Northern Africa and Australia-New Zealand had the lowest. Very high HDI countries had the highest incidence, and low HDI countries had the second-highest incidence. Cervical cancer accounted for the majority of cases and deaths, with Eswatini recording the highest statistics. Projections indicate a 49.61% increase in new cases and a 77.23% increase in deaths by 2050, with the highest increases in Eastern Africa, Middle Africa, Northern Africa, Western Africa, Western Asia, and Melanesia. The study highlights the need for effective interventions, including early screening, improved healthcare infrastructure, and targeted prevention strategies to address the growing burden of GCs globally.The study evaluates the global burden of gynecological cancers (GCs) in 2022 and projects future trends up to 2050. In 2022, there were 1,473,427 new cases and 680,372 deaths from GCs, with significant regional disparities. Eastern Africa had the highest incidence and mortality rates, while Northern Africa and Australia-New Zealand had the lowest. Very high HDI countries had the highest incidence, and low HDI countries had the second-highest incidence. Cervical cancer accounted for the majority of cases and deaths, with Eswatini recording the highest statistics. Projections indicate a 49.61% increase in new cases and a 77.23% increase in deaths by 2050, with the highest increases in Eastern Africa, Middle Africa, Northern Africa, Western Africa, Western Asia, and Melanesia. The study highlights the need for effective interventions, including early screening, improved healthcare infrastructure, and targeted prevention strategies to address the growing burden of GCs globally.