A global consensus statement on simulation-based practice in healthcare emphasizes the critical role of simulation in addressing healthcare challenges, reducing education inequities, and improving patient outcomes. Simulation enhances healthcare processes and systems, contributing to a safety culture within organizations. It is cost-effective and successful in improving team performance, fostering workforce resilience, and enhancing patient outcomes. The statement, developed through an international collaborative effort involving 50 societies across 67 countries, aims to establish a consensus on key priorities for the broad adoption of exemplary simulation practice globally. Key recommendations include advocating for the benefits of simulation for patients, staff, and organizations, promoting its adoption and integration into daily learning and practice across healthcare. Low-cost, high-impact simulation methods should be used to expand global accessibility and integrate into system improvement processes and curricula. Support at institutional and governmental levels is essential, requiring a unified approach in terms of political, strategic, and financial commitment. Simulation should be used appropriately, employing evidence-based quality assurance approaches that adhere to recognized standards of best practice, including faculty development, evaluation, accreditation, credentialing, and certification. Equitable and sustainable access to high-quality, contextually relevant simulation-based learning opportunities is crucial, with a renewed emphasis on research and scholarship in this field. The statement calls on policymakers and leaders to formally acknowledge and embrace the benefits of simulation in healthcare practice and education. Healthcare systems and education institutions should commit to high-quality healthcare and improved patient outcomes, supporting simulation-based learning opportunities for individuals and interprofessional teams. Simulation practitioners are urged to champion healthcare simulation as an indispensable learning tool, adhere to best practice standards, maintain a commitment to lifelong learning, and persist in their advocacy for patient safety. The global consensus statement aims to establish a unified global position on needs, solutions, and priorities, emphasizing the crucial role of simulation in enhancing healthcare practices and education. It highlights the need for a shared safety culture, diversity, equity, inclusion, and accessibility principles in simulation and healthcare practice. The statement also addresses the environmental impact of simulation activities and encourages a renewed emphasis on research and scholarship. The statement calls for a concerted effort by leaders and policymakers, healthcare systems, healthcare education institutions, and simulation practitioners to promote and enhance this critical capability as a means of improving patient outcomes globally. It emphasizes the importance of simulation in adapting to changing demands on healthcare systems, supporting the development of skills for health and social care professionals, and improving team performance in managing trauma victims and mass casualty disasters. The statement also highlights the ongoing transformation of healthcare practice and education from technological developments, emphasizing the need for innovative methods for management and interpretation of health data.A global consensus statement on simulation-based practice in healthcare emphasizes the critical role of simulation in addressing healthcare challenges, reducing education inequities, and improving patient outcomes. Simulation enhances healthcare processes and systems, contributing to a safety culture within organizations. It is cost-effective and successful in improving team performance, fostering workforce resilience, and enhancing patient outcomes. The statement, developed through an international collaborative effort involving 50 societies across 67 countries, aims to establish a consensus on key priorities for the broad adoption of exemplary simulation practice globally. Key recommendations include advocating for the benefits of simulation for patients, staff, and organizations, promoting its adoption and integration into daily learning and practice across healthcare. Low-cost, high-impact simulation methods should be used to expand global accessibility and integrate into system improvement processes and curricula. Support at institutional and governmental levels is essential, requiring a unified approach in terms of political, strategic, and financial commitment. Simulation should be used appropriately, employing evidence-based quality assurance approaches that adhere to recognized standards of best practice, including faculty development, evaluation, accreditation, credentialing, and certification. Equitable and sustainable access to high-quality, contextually relevant simulation-based learning opportunities is crucial, with a renewed emphasis on research and scholarship in this field. The statement calls on policymakers and leaders to formally acknowledge and embrace the benefits of simulation in healthcare practice and education. Healthcare systems and education institutions should commit to high-quality healthcare and improved patient outcomes, supporting simulation-based learning opportunities for individuals and interprofessional teams. Simulation practitioners are urged to champion healthcare simulation as an indispensable learning tool, adhere to best practice standards, maintain a commitment to lifelong learning, and persist in their advocacy for patient safety. The global consensus statement aims to establish a unified global position on needs, solutions, and priorities, emphasizing the crucial role of simulation in enhancing healthcare practices and education. It highlights the need for a shared safety culture, diversity, equity, inclusion, and accessibility principles in simulation and healthcare practice. The statement also addresses the environmental impact of simulation activities and encourages a renewed emphasis on research and scholarship. The statement calls for a concerted effort by leaders and policymakers, healthcare systems, healthcare education institutions, and simulation practitioners to promote and enhance this critical capability as a means of improving patient outcomes globally. It emphasizes the importance of simulation in adapting to changing demands on healthcare systems, supporting the development of skills for health and social care professionals, and improving team performance in managing trauma victims and mass casualty disasters. The statement also highlights the ongoing transformation of healthcare practice and education from technological developments, emphasizing the need for innovative methods for management and interpretation of health data.