The global consensus statement on simulation-based practice in healthcare highlights the pivotal role of simulation in addressing universal healthcare challenges, reducing educational inequities, and improving patient outcomes. The statement, developed through an international collaborative effort involving 50 societies across 67 countries, emphasizes the benefits of simulation for patients, staff, and organizations. Key recommendations include advocating for the integration of simulation into daily learning and practice, leveraging low-cost, high-impact methods, and ensuring equitable access to high-quality simulation-based learning opportunities. The statement calls for sustained political, strategic, and financial support, adherence to best practice standards, and a commitment to lifelong learning and patient safety. It also underscores the importance of ethical considerations, diversity, equity, inclusion, and sustainability in simulation practices. The authors urge policymakers, healthcare leaders, education institutions, and simulation practitioners to embrace simulation as a critical tool for enhancing healthcare practices and improving patient outcomes globally.The global consensus statement on simulation-based practice in healthcare highlights the pivotal role of simulation in addressing universal healthcare challenges, reducing educational inequities, and improving patient outcomes. The statement, developed through an international collaborative effort involving 50 societies across 67 countries, emphasizes the benefits of simulation for patients, staff, and organizations. Key recommendations include advocating for the integration of simulation into daily learning and practice, leveraging low-cost, high-impact methods, and ensuring equitable access to high-quality simulation-based learning opportunities. The statement calls for sustained political, strategic, and financial support, adherence to best practice standards, and a commitment to lifelong learning and patient safety. It also underscores the importance of ethical considerations, diversity, equity, inclusion, and sustainability in simulation practices. The authors urge policymakers, healthcare leaders, education institutions, and simulation practitioners to embrace simulation as a critical tool for enhancing healthcare practices and improving patient outcomes globally.