The article by Bernadette Modell and Matthew Darlison discusses the global epidemiology of hemoglobin disorders and the development of service indicators to assess the needs for equitable and cost-effective treatment and prevention. The authors compiled demographic and prevalence data on gene variants responsible for hemoglobin disorders from various sources, establishing a global database that includes five practical service indicators to measure the need for care and prevention. They found that hemoglobin disorders are a significant health problem in 71% of 229 countries, affecting 89% of all births worldwide. Over 330,000 affected infants are born annually, with sickle cell disorders accounting for 83% and thalassemias for 17%. Hemoglobin disorders contribute to about 3.4% of deaths in children under 5 years old. The authors emphasize the importance of carrier screening, genetic counseling, and prenatal diagnosis to reduce the impact of these disorders. They also highlight the need for integrated health services that include genetic approaches to manage hemoglobin disorders effectively.The article by Bernadette Modell and Matthew Darlison discusses the global epidemiology of hemoglobin disorders and the development of service indicators to assess the needs for equitable and cost-effective treatment and prevention. The authors compiled demographic and prevalence data on gene variants responsible for hemoglobin disorders from various sources, establishing a global database that includes five practical service indicators to measure the need for care and prevention. They found that hemoglobin disorders are a significant health problem in 71% of 229 countries, affecting 89% of all births worldwide. Over 330,000 affected infants are born annually, with sickle cell disorders accounting for 83% and thalassemias for 17%. Hemoglobin disorders contribute to about 3.4% of deaths in children under 5 years old. The authors emphasize the importance of carrier screening, genetic counseling, and prenatal diagnosis to reduce the impact of these disorders. They also highlight the need for integrated health services that include genetic approaches to manage hemoglobin disorders effectively.