Coxsackieviruses (CVs) are a group of enteroviruses that cause a wide spectrum of human diseases, ranging from mild to severe conditions. This review provides an overview of the recent studies and findings on CV-associated disorders, along with epidemiological data on the distribution, variability, and clinical manifestations of different CV types. CVs have 27 identified genotypes, and their infections can lead to various neurological disorders, including neurodegenerative illnesses and cognitive impacts. The review highlights the role of CVs in oncolytic virotherapy and the importance of understanding their pathogenicity to design effective surveillance and prevention strategies. CVs are transmitted through oral or fecal routes and can cause infections in multiple organs, including the skin, respiratory system, muscles, heart, genitourinary system, gastrointestinal tract, liver, and central nervous system. The review also discusses the diagnostic methods for CV infections, emphasizing the importance of early detection and genetic characterization. Overall, the review underscores the need for further research to better understand the complex interactions between CVs and the human body, as well as to develop more effective treatments and preventive measures.Coxsackieviruses (CVs) are a group of enteroviruses that cause a wide spectrum of human diseases, ranging from mild to severe conditions. This review provides an overview of the recent studies and findings on CV-associated disorders, along with epidemiological data on the distribution, variability, and clinical manifestations of different CV types. CVs have 27 identified genotypes, and their infections can lead to various neurological disorders, including neurodegenerative illnesses and cognitive impacts. The review highlights the role of CVs in oncolytic virotherapy and the importance of understanding their pathogenicity to design effective surveillance and prevention strategies. CVs are transmitted through oral or fecal routes and can cause infections in multiple organs, including the skin, respiratory system, muscles, heart, genitourinary system, gastrointestinal tract, liver, and central nervous system. The review also discusses the diagnostic methods for CV infections, emphasizing the importance of early detection and genetic characterization. Overall, the review underscores the need for further research to better understand the complex interactions between CVs and the human body, as well as to develop more effective treatments and preventive measures.