This study provides a comprehensive bibliometric and visualized analysis of global research progress on gut microbiota and epigenetics. The research covers 460 articles from 71 countries, with a steady increase in publications since 2011. The United States, People's Republic of China, and Italy are at the center of this field, with major research institutions including the University of California System, Harvard University, and the University of London. Key authors in this field include Li, X, Yu, Q, Zhang, S X, and He, P F. The study identifies research hotspots and frontiers, including the role of short-chain fatty acids (SCFAs) in gut microbiota and epigenetic mechanisms, the impact of gut microbiota and epigenetics on host obesity, diet, and metabolism, and their association with colorectal cancer, breast cancer, and inflammatory bowel disease. It also highlights the role of the gut-brain axis in regulating epigenetics and its impact on psychiatric diseases. Probiotics are suggested to regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases. The study concludes that this is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research, providing guidance for future research directions. The study emphasizes the importance of SCFAs in the mechanism between gut microbiota and epigenetics, and their role in host obesity, diet, and metabolism. The research also highlights the relationship between gut microbiota and epigenetics in colorectal cancer, breast cancer, and inflammatory bowel disease, as well as the impact of gut microbiota on psychiatric diseases through the gut-brain axis. The study suggests that probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases. The research provides insights into the relationship between gut microbiota and epigenetics, and the potential for future research in this area.This study provides a comprehensive bibliometric and visualized analysis of global research progress on gut microbiota and epigenetics. The research covers 460 articles from 71 countries, with a steady increase in publications since 2011. The United States, People's Republic of China, and Italy are at the center of this field, with major research institutions including the University of California System, Harvard University, and the University of London. Key authors in this field include Li, X, Yu, Q, Zhang, S X, and He, P F. The study identifies research hotspots and frontiers, including the role of short-chain fatty acids (SCFAs) in gut microbiota and epigenetic mechanisms, the impact of gut microbiota and epigenetics on host obesity, diet, and metabolism, and their association with colorectal cancer, breast cancer, and inflammatory bowel disease. It also highlights the role of the gut-brain axis in regulating epigenetics and its impact on psychiatric diseases. Probiotics are suggested to regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases. The study concludes that this is the first comprehensive and in-depth bibliometric study of trends and developments in the field of gut microbiota and epigenetics research, providing guidance for future research directions. The study emphasizes the importance of SCFAs in the mechanism between gut microbiota and epigenetics, and their role in host obesity, diet, and metabolism. The research also highlights the relationship between gut microbiota and epigenetics in colorectal cancer, breast cancer, and inflammatory bowel disease, as well as the impact of gut microbiota on psychiatric diseases through the gut-brain axis. The study suggests that probiotics can regulate gut microbiota, improve lifestyle, and reduce the occurrence and development of diseases. The research provides insights into the relationship between gut microbiota and epigenetics, and the potential for future research in this area.