This review examines the global trends in diabetes-related complications, highlighting the increasing prevalence of diabetes worldwide and its impact on chronic and acute diseases. The study focuses on macrovascular and microvascular complications, including cardiovascular disease (CVD), end-stage renal disease (ESRD), retinopathy, neuropathy, and lower-extremity amputations (LEAs). Despite a decline in CVD mortality and hospitalizations for major CVD events among people with diabetes, the risk remains significantly higher compared to those without diabetes. Trends in ESRD, diabetic retinopathy, and neuropathy are less well-documented, but data suggest a decline in LEAs and acute complications. The review also discusses emerging complications such as infections, cancers, and physical and cognitive disabilities, which are becoming more prominent due to the increasing life expectancy of people with diabetes. The authors emphasize the need for standardized reporting methods and practical registries to monitor global trends in diabetes complications, particularly in low- and middle-income countries, where data are currently lacking.This review examines the global trends in diabetes-related complications, highlighting the increasing prevalence of diabetes worldwide and its impact on chronic and acute diseases. The study focuses on macrovascular and microvascular complications, including cardiovascular disease (CVD), end-stage renal disease (ESRD), retinopathy, neuropathy, and lower-extremity amputations (LEAs). Despite a decline in CVD mortality and hospitalizations for major CVD events among people with diabetes, the risk remains significantly higher compared to those without diabetes. Trends in ESRD, diabetic retinopathy, and neuropathy are less well-documented, but data suggest a decline in LEAs and acute complications. The review also discusses emerging complications such as infections, cancers, and physical and cognitive disabilities, which are becoming more prominent due to the increasing life expectancy of people with diabetes. The authors emphasize the need for standardized reporting methods and practical registries to monitor global trends in diabetes complications, particularly in low- and middle-income countries, where data are currently lacking.