The chapter "Glutathione Transferases" by David P. Dixon and Robert Edwards provides an in-depth review of the 55 Arabidopsis glutathione transferases (GSTs), which are classified into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR), and TCHQD classes. The phi and tau classes are highly stress-inducible and frequently appear in proteomic and transcriptomic studies, but their natural roles remain unclear. The smaller DHAR and lambda classes are likely glutathione-dependent reductases, the zeta class functions in tyrosine catabolism, and the theta class may detoxify oxidized lipids. The review discusses the evidence for the functional roles of GSTs and their potential for diverse functions beyond xenobiotic detoxification. It covers the history of GST discovery, their structure, post-translational modifications, expression patterns, and specific functions within different classes. The phi class, particularly GSTF2, is well-studied and involved in various cellular processes, including flavonoid transport and stress responses. The tau class, the most numerous, is auxin-responsive and may play a role in intracellular transport of fatty acid-derived molecules. The chapter also highlights the importance of GSTs in plant defense-related secondary metabolism and their potential roles in modulating gene transcription and detoxifying oxidized DNA.The chapter "Glutathione Transferases" by David P. Dixon and Robert Edwards provides an in-depth review of the 55 Arabidopsis glutathione transferases (GSTs), which are classified into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR), and TCHQD classes. The phi and tau classes are highly stress-inducible and frequently appear in proteomic and transcriptomic studies, but their natural roles remain unclear. The smaller DHAR and lambda classes are likely glutathione-dependent reductases, the zeta class functions in tyrosine catabolism, and the theta class may detoxify oxidized lipids. The review discusses the evidence for the functional roles of GSTs and their potential for diverse functions beyond xenobiotic detoxification. It covers the history of GST discovery, their structure, post-translational modifications, expression patterns, and specific functions within different classes. The phi class, particularly GSTF2, is well-studied and involved in various cellular processes, including flavonoid transport and stress responses. The tau class, the most numerous, is auxin-responsive and may play a role in intracellular transport of fatty acid-derived molecules. The chapter also highlights the importance of GSTs in plant defense-related secondary metabolism and their potential roles in modulating gene transcription and detoxifying oxidized DNA.