This study compared the prognostic value of glycated hemoglobin and fasting glucose in identifying adults at risk for diabetes or cardiovascular disease. The researchers measured glycated hemoglobin in whole-blood samples from 11,092 black or white adults who did not have a history of diabetes or cardiovascular disease. The results showed that glycated hemoglobin values were associated with a higher risk of diabetes and more strongly associated with risks of cardiovascular disease and death from any cause compared to fasting glucose levels. Specifically, higher glycated hemoglobin values were linked to increased risks of diagnosed diabetes, coronary heart disease, ischemic stroke, and death from any cause. The associations remained significant even after adjusting for baseline fasting glucose levels. Additionally, the addition of glycated hemoglobin to models including fasting glucose improved risk discrimination for coronary heart disease. The study concluded that glycated hemoglobin is a useful diagnostic test for diabetes and a marker of cardiovascular risk, suggesting its potential value in clinical practice.This study compared the prognostic value of glycated hemoglobin and fasting glucose in identifying adults at risk for diabetes or cardiovascular disease. The researchers measured glycated hemoglobin in whole-blood samples from 11,092 black or white adults who did not have a history of diabetes or cardiovascular disease. The results showed that glycated hemoglobin values were associated with a higher risk of diabetes and more strongly associated with risks of cardiovascular disease and death from any cause compared to fasting glucose levels. Specifically, higher glycated hemoglobin values were linked to increased risks of diagnosed diabetes, coronary heart disease, ischemic stroke, and death from any cause. The associations remained significant even after adjusting for baseline fasting glucose levels. Additionally, the addition of glycated hemoglobin to models including fasting glucose improved risk discrimination for coronary heart disease. The study concluded that glycated hemoglobin is a useful diagnostic test for diabetes and a marker of cardiovascular risk, suggesting its potential value in clinical practice.