The article reviews the current advancements in the field of graphene bioapplications, focusing on the biofunctionalization of graphene and its derivatives for biological and biotechnological uses. It highlights the unique properties of graphene, such as its planar structure, electronic flexibility, high surface area, and thermal conductivity, which make it a promising material for various applications. The review discusses the biofunctionalization of graphene with DNA and proteins, including the development of biosensors based on fluorescence resonance energy transfer (FRET) and the use of graphene for drug delivery and cell imaging. The article also addresses the challenges and future perspectives in this rapidly developing area, emphasizing the need for further research to optimize the performance and safety of graphene-based materials in biological and medical applications.The article reviews the current advancements in the field of graphene bioapplications, focusing on the biofunctionalization of graphene and its derivatives for biological and biotechnological uses. It highlights the unique properties of graphene, such as its planar structure, electronic flexibility, high surface area, and thermal conductivity, which make it a promising material for various applications. The review discusses the biofunctionalization of graphene with DNA and proteins, including the development of biosensors based on fluorescence resonance energy transfer (FRET) and the use of graphene for drug delivery and cell imaging. The article also addresses the challenges and future perspectives in this rapidly developing area, emphasizing the need for further research to optimize the performance and safety of graphene-based materials in biological and medical applications.