The Guide to Receptors and Channels (GRAC), 3rd edition, is a comprehensive resource designed to organize and condense information on a wide range of established and potential pharmacological targets. The guide aims to provide an authoritative yet user-friendly publication, allowing newcomers to quickly identify the key properties of various target groups. Each entry focuses on a specific target class family, typically presented on a single page for easy access and overview. The targets are selected based on sufficient pharmacological information or clear community interest. The guide prioritizes human receptor data, with links to structural information through the Ensembl database. It includes new records, expanding by nearly 20% compared to the 2nd edition, and introduces lists of 'orphan' 7-transmembrane and nuclear receptors. The editors compiled the records with input from consultants and experts, adhering to nomenclature guidelines from the International Pharmacological Congress (NC-IUPHAR). The guide is divided into seven sections covering different types of pharmacological targets, and it provides tabulated data for comparison of selective agents and probes. Citations to the guide should follow a specific format, as detailed in the references.The Guide to Receptors and Channels (GRAC), 3rd edition, is a comprehensive resource designed to organize and condense information on a wide range of established and potential pharmacological targets. The guide aims to provide an authoritative yet user-friendly publication, allowing newcomers to quickly identify the key properties of various target groups. Each entry focuses on a specific target class family, typically presented on a single page for easy access and overview. The targets are selected based on sufficient pharmacological information or clear community interest. The guide prioritizes human receptor data, with links to structural information through the Ensembl database. It includes new records, expanding by nearly 20% compared to the 2nd edition, and introduces lists of 'orphan' 7-transmembrane and nuclear receptors. The editors compiled the records with input from consultants and experts, adhering to nomenclature guidelines from the International Pharmacological Congress (NC-IUPHAR). The guide is divided into seven sections covering different types of pharmacological targets, and it provides tabulated data for comparison of selective agents and probes. Citations to the guide should follow a specific format, as detailed in the references.