Guidelines for the Prevention of Intravascular Catheter-related Infections were developed by a multidisciplinary working group, including experts from critical care medicine, infectious diseases, healthcare infection control, surgery, anesthesiology, interventional radiology, pulmonary medicine, pediatric medicine, and nursing. These guidelines aim to provide evidence-based recommendations to prevent intravascular catheter-related infections (CRBSI). Key recommendations include educating and training healthcare personnel, using maximal sterile barrier precautions during catheter insertion, using a >0.5% chlorhexidine skin preparation with alcohol for antisepsis, avoiding routine replacement of central venous catheters, and using antiseptic/antibiotic impregnated short-term central venous catheters and chlorhexidine impregnated sponge dressings when infection rates are not decreasing despite adherence to other strategies. The guidelines emphasize performance improvement through bundled strategies and documentation of compliance rates for quality assurance. Major areas of emphasis include education and training for healthcare personnel, selection of catheters and sites, hand hygiene and aseptic technique, maximal sterile barrier precautions, skin preparation, catheter site dressing regimens, patient cleansing, catheter securement devices, antimicrobial/antiseptic impregnated catheters and cuffs, systemic antibiotic prophylaxis, antibiotic/antiseptic ointments, antibiotic lock prophylaxis, anticoagulants, replacement of peripheral and midline catheters, replacement of CVCs, umbilical catheters, peripheral arterial catheters and pressure monitoring devices, replacement of administration sets, needleless intravascular catheter systems, and performance improvement. The guidelines categorize recommendations based on scientific data, theoretical rationale, applicability, and economic impact. Category IA recommendations are strongly supported by well-designed studies, Category IB are supported by some studies and theoretical rationale or accepted practices, Category IC are required by regulations, Category II are suggested based on studies or theoretical rationale, and unresolved issues lack sufficient evidence or consensus. The guidelines aim to reduce the incidence of CRBSI by implementing bundled strategies, ensuring proper catheter selection and site, maintaining aseptic technique, and using appropriate antiseptics and dressings. The goal is to minimize infection rates while considering patient-specific factors and the limitations of current strategies and technologies.Guidelines for the Prevention of Intravascular Catheter-related Infections were developed by a multidisciplinary working group, including experts from critical care medicine, infectious diseases, healthcare infection control, surgery, anesthesiology, interventional radiology, pulmonary medicine, pediatric medicine, and nursing. These guidelines aim to provide evidence-based recommendations to prevent intravascular catheter-related infections (CRBSI). Key recommendations include educating and training healthcare personnel, using maximal sterile barrier precautions during catheter insertion, using a >0.5% chlorhexidine skin preparation with alcohol for antisepsis, avoiding routine replacement of central venous catheters, and using antiseptic/antibiotic impregnated short-term central venous catheters and chlorhexidine impregnated sponge dressings when infection rates are not decreasing despite adherence to other strategies. The guidelines emphasize performance improvement through bundled strategies and documentation of compliance rates for quality assurance. Major areas of emphasis include education and training for healthcare personnel, selection of catheters and sites, hand hygiene and aseptic technique, maximal sterile barrier precautions, skin preparation, catheter site dressing regimens, patient cleansing, catheter securement devices, antimicrobial/antiseptic impregnated catheters and cuffs, systemic antibiotic prophylaxis, antibiotic/antiseptic ointments, antibiotic lock prophylaxis, anticoagulants, replacement of peripheral and midline catheters, replacement of CVCs, umbilical catheters, peripheral arterial catheters and pressure monitoring devices, replacement of administration sets, needleless intravascular catheter systems, and performance improvement. The guidelines categorize recommendations based on scientific data, theoretical rationale, applicability, and economic impact. Category IA recommendations are strongly supported by well-designed studies, Category IB are supported by some studies and theoretical rationale or accepted practices, Category IC are required by regulations, Category II are suggested based on studies or theoretical rationale, and unresolved issues lack sufficient evidence or consensus. The guidelines aim to reduce the incidence of CRBSI by implementing bundled strategies, ensuring proper catheter selection and site, maintaining aseptic technique, and using appropriate antiseptics and dressings. The goal is to minimize infection rates while considering patient-specific factors and the limitations of current strategies and technologies.