The World Health Organization (WHO) has published guidelines for the safe use of wastewater, excreta, and greywater, specifically focusing on wastewater use in agriculture. These guidelines aim to ensure the safe and effective use of wastewater in agriculture to maximize public health benefits and environmental sustainability. The guidelines are based on scientific evidence and are designed to protect the health of farmers, their families, local communities, and consumers of agricultural products. They take into account national, sociocultural, economic, and environmental factors and provide minimum procedures and specific health-based targets for safe use. The guidelines emphasize the importance of risk assessment and management, including the evaluation of health risks, microbial hazards, and toxic chemicals. They provide a framework for developing health-based targets and health protection measures to reduce the risks associated with wastewater use in agriculture. The guidelines also address the need for monitoring and system assessment to ensure that the use of wastewater is safe and effective. The guidelines are divided into four volumes, with Volume 2 focusing on wastewater use in agriculture. The guidelines are intended to be used as a basis for developing international and national approaches to managing health risks associated with wastewater use in agriculture. They are also relevant for situations where faecally contaminated water is used for irrigation unintentionally. The guidelines are based on the Stockholm Framework, which provides a harmonized approach to risk assessment and management for water-related diseases. The framework involves the assessment of health risks prior to the setting of health-based targets and the development of guideline values. The guidelines also include a substantive revision of approaches to ensuring microbial safety. The guidelines are recognized as representing the position of the United Nations system on issues of wastewater, excreta, and greywater use and health. They are intended to be useful to all those concerned with issues relating to the safe use of wastewater, excreta, and greywater, public health, water resources development, and wastewater management. The target audience includes public health, agricultural, and environmental scientists, agriculture professionals, educators, researchers, engineers, policy-makers, and those responsible for developing standards and regulations.The World Health Organization (WHO) has published guidelines for the safe use of wastewater, excreta, and greywater, specifically focusing on wastewater use in agriculture. These guidelines aim to ensure the safe and effective use of wastewater in agriculture to maximize public health benefits and environmental sustainability. The guidelines are based on scientific evidence and are designed to protect the health of farmers, their families, local communities, and consumers of agricultural products. They take into account national, sociocultural, economic, and environmental factors and provide minimum procedures and specific health-based targets for safe use. The guidelines emphasize the importance of risk assessment and management, including the evaluation of health risks, microbial hazards, and toxic chemicals. They provide a framework for developing health-based targets and health protection measures to reduce the risks associated with wastewater use in agriculture. The guidelines also address the need for monitoring and system assessment to ensure that the use of wastewater is safe and effective. The guidelines are divided into four volumes, with Volume 2 focusing on wastewater use in agriculture. The guidelines are intended to be used as a basis for developing international and national approaches to managing health risks associated with wastewater use in agriculture. They are also relevant for situations where faecally contaminated water is used for irrigation unintentionally. The guidelines are based on the Stockholm Framework, which provides a harmonized approach to risk assessment and management for water-related diseases. The framework involves the assessment of health risks prior to the setting of health-based targets and the development of guideline values. The guidelines also include a substantive revision of approaches to ensuring microbial safety. The guidelines are recognized as representing the position of the United Nations system on issues of wastewater, excreta, and greywater use and health. They are intended to be useful to all those concerned with issues relating to the safe use of wastewater, excreta, and greywater, public health, water resources development, and wastewater management. The target audience includes public health, agricultural, and environmental scientists, agriculture professionals, educators, researchers, engineers, policy-makers, and those responsible for developing standards and regulations.